Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Cancer Research
  Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 289-299
DOI: 10.3923/ijcr.2011.289.299
Dietary Fiber and DMBA-induced Rat Mammary Carcinomas
Paula C. Pereira, A. Filipa Vicente, Maria F. Mesquita and Antonio S. Cabrita

Abstract:
Dietary fiber had been previously associated with breast cancer risk but some controversies remain on the role of insoluble fiber type. The aim of the present study was to evaluate the effect of a fiber rich food in an experimental model of mammary carcinogenesis. Animals from study groups received a fiber rich food and were compared with two control groups receiving standard food, two groups received the administration of a common carcinogen and histopathological and blood analysis were conducted. Only four tumors were found on group receiving fiber and the carcinogen against the thirty three tumors found on group receiving only the carcinogen and standard food. Additionally, blood cholesterol and triglycerides were significantly lower in this group (p<0.05). Glycaemia was also lower but without significance. The experimental results had shown a possible protective effect of fiber on mammary carcinomas possible due to carcinogen binding, weight-gain prevention and insulin sensitivity. Further studies should address the effect of the several fiber types on mammary carcinogenesis process.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Determination of Processing Effects on Phytochemical Content, Antioxidants Activity and Chemopreventive Potential of Beets (Beta vulgaris) using a Colon Cancer Fisher 344 Male Rat Model
  •    Chemopreventive Effect of Chlorella on the Antioxidant System in 7, 12-Dimethylbenz[a]Anthracene-Induced Oxidative Stress in Liver
  •    Protective Effect of Green Alage Against 7,12-Dimethylbenzanthracene (DMBA)-Induced Breast Cancer in Rats
  •    Fiber Digestion in Mammals
  •    Study on the Enraging Severity of Cancer in West Bengal, India from 2003 to 2010
How to cite this article:

Paula C. Pereira, A. Filipa Vicente, Maria F. Mesquita and Antonio S. Cabrita, 2011. Dietary Fiber and DMBA-induced Rat Mammary Carcinomas. International Journal of Cancer Research, 7: 289-299.

DOI: 10.3923/ijcr.2011.289.299

URL: https://scialert.net/abstract/?doi=ijcr.2011.289.299

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

Curve Bottom