Submit Manuscript

International Journal of Cancer Research

Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 278-288
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 390

Search

Authors

Sabry A. EL-Naggar

Ahmed A. El-Barbary

Merveet A. Mansour

Fawzya Abdel-Shafy

Shaimaa Talat

Keywords

Recently, identifying new chemo-preventive agents to replace the current chemotherapies consider one of the most important approaches which could be crucial for cancer treatment. The present study was conducted to evaluate the anti-tumor activity of some newly synthesized heterocyclic 1,3,4-thiadiazole and 1,2,4-triazine derivatives. Different groups of mice were inoculated with Ehrlichs Ascites Carcinoma cells (EAC) intra-peritoneal (i.p.) (2x106 cells mouse-1). After one day of inculcation, mice were treated either with cisplatin (reference drug) or with twenty five different new derivatives of 1,3,4-thiadiazoles or 1,2,4-triazines. The anti-tumor activity of these derivatives against EAC-bearing mice were monitored through the changes in the total body weight, total ascetic volume, the number of live and dead tumor cells, median survival time (MST) and some biochemical parameters. The results showed that only five compounds of 1,3,4-thiadiazoles significantly inhibited the tumor progression after 14 days of the treatment. Interestingly, two of these compounds increased the life span of the tumored mice by 34 and 40% when compared with the untreated group. In contrast, all 1,2,4-triazine derivatives didn’t show any potential anti-tumor activity against EAC-model. In conclusion, screening of 1,3,4-thiadiazole derivatives showed a potential activity against EAC while, 1,2,4-triazine derivatives didn’t show any marked anti-tumor activity.
PDF Fulltext XML References Citation

Related Articles

Experimental Approach to Treatment of Colorectal Cancer by Herbs and Their Constituents: An Overview on in vivo and in vitro Protocols and Molecular Targets
Numerical Simulation of Tumor Development Stages Using Artificial Neural Network
Anti-cancerous Plants of Uttarakhand Himalaya: A Review
Chemopreventive Effect of Oil, Extracted from Coriandrum sativum on Mice Bearing Solid Ehrlich Tumor
Antitumor Efficacy of Salenostemma Argel and/or γ-Irradiation Against Ehrlich Carcinoma
Antitumour Activity of cis-bis{imidazo(1,2-α)- pyridineplatinum (II)
Potential Anticancer Natural Product Against Human Lung Cancer Cells

Leave a Comment

Your email address will not be published. Required fields are marked *