
	International Journal of Cancer Research
	Year: 2011 \| Volume: 7 \| Issue: 4 \| Page No.: 278-288 DOI: 10.3923/ijcr.2011.278.288

Anti-tumor Activity of Some 1,3,4-thiadiazoles and 1,2,4-triazine Derivatives against Ehrlichs Ascites Carcinoma

Sabry A. EL-Naggar, Ahmed A. El-Barbary, Merveet A. Mansour, Fawzya Abdel-Shafy and Shaimaa Talat

Abstract: Recently, identifying new chemo-preventive agents to replace the current chemotherapies consider one of the most important approaches which could be crucial for cancer treatment. The present study was conducted to evaluate the anti-tumor activity of some newly synthesized heterocyclic 1,3,4-thiadiazole and 1,2,4-triazine derivatives. Different groups of mice were inoculated with Ehrlichs Ascites Carcinoma cells (EAC) intra-peritoneal (i.p.) (2x10⁶ cells mouse^-1). After one day of inculcation, mice were treated either with cisplatin (reference drug) or with twenty five different new derivatives of 1,3,4-thiadiazoles or 1,2,4-triazines. The anti-tumor activity of these derivatives against EAC-bearing mice were monitored through the changes in the total body weight, total ascetic volume, the number of live and dead tumor cells, median survival time (MST) and some biochemical parameters. The results showed that only five compounds of 1,3,4-thiadiazoles significantly inhibited the tumor progression after 14 days of the treatment. Interestingly, two of these compounds increased the life span of the tumored mice by 34 and 40% when compared with the untreated group. In contrast, all 1,2,4-triazine derivatives didn’t show any potential anti-tumor activity against EAC-model. In conclusion, screening of 1,3,4-thiadiazole derivatives showed a potential activity against EAC while, 1,2,4-triazine derivatives didn’t show any marked anti-tumor activity.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Experimental Approach to Treatment of Colorectal Cancer by Herbs and Their Constituents: An Overview on in vivo and in vitro Protocols and Molecular Targets

•	Numerical Simulation of Tumor Development Stages Using Artificial Neural Network

•	Anti-cancerous Plants of Uttarakhand Himalaya: A Review

•	Chemopreventive Effect of Oil, Extracted from Coriandrum sativum on Mice Bearing Solid Ehrlich Tumor

•	Antitumor Efficacy of Salenostemma Argel and/or γ-Irradiation Against Ehrlich Carcinoma

•	Antitumour Activity of cis-bis{imidazo(1,2-α)- pyridineplatinum (II)

How to cite this article:

Sabry A. EL-Naggar, Ahmed A. El-Barbary, Merveet A. Mansour, Fawzya Abdel-Shafy and Shaimaa Talat, 2011. Anti-tumor Activity of Some 1,3,4-thiadiazoles and 1,2,4-triazine Derivatives against Ehrlichs Ascites Carcinoma. International Journal of Cancer Research, 7: 278-288.

DOI: 10.3923/ijcr.2011.278.288

URL: https://scialert.net/abstract/?doi=ijcr.2011.278.288

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		FSTA
		SCIMAGO

Science Alert