• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Cancer Research
  2. Vol 7 (4), 2011
  3. 267-277
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Cancer Research

Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 267-277
DOI: 10.3923/ijcr.2011.267.277

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 239

Authors


Chandrashekhar G. Joshi

Country: India

M. Gopal

Country: India

N. Suchetha Kumari

Country: India

Keywords


  • ascites tumor
  • Tragia involucrata
  • flavonoids
  • phenolic compounds
  • toxicity
Research Article

Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata

Chandrashekhar G. Joshi, M. Gopal and N. Suchetha Kumari
The practice of traditional medicines in treatment of cancer is based on the knowledge and use of plant based medicine since ancient time. The study of folk medicinal practices revealed the use of Tragia involucrata (Euphorbiaceae) along with other medicinal plants to treat certain tumours in some parts of Kerala, India. The aim of the present study was to evaluate the antitumor potential of hexane and ethyl acetate extracts (HE and EAE) and to asses the antioxidant activity of EAE of T. involucrata. The mice were injected with 106 Ehrlich’s Ascites Carcinoma (EAC) cells subcutaneously and the extracts were administered intra-peritoneal (i.p.). In vitro antioxidant property of EAE was tested by 2, 2’-azinobis (3-ethylbenzo-thiozoline-6-sulphonic acid (ABTS)) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. In vivo antioxidant potential of EAE was determined by nitric-oxide by Griess-reagent method, total antioxidant in serum by phosphomolybdenum method and super oxide dismutase by nitroblue tetrazolium (NBT) method. Administration of the extracts to mice challenged with EAC showed significant antitumour activity. The observed antitumor activity of the extracts was dose dependant. There was a significant increase in the percentage life span (ILS %) in extract treated mice. HE was not toxic to mice even at the dose of 2000 mg kg-1 body weight. EAE was toxic to animals when the dosage was increased beyond 150 mg kg-1 . EAE was showing even a significant in vitro as well as in vivo antioxidant activity. In vivo antioxidant activity was showing the reciprocal dose response. From the results it may be concluded that the plant posses antitumor activity as claimed in traditional practices.
PDF Fulltext XML References Citation

How to cite this article

Chandrashekhar G. Joshi, M. Gopal and N. Suchetha Kumari, 2011. Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata. International Journal of Cancer Research, 7: 267-277.

DOI: 10.3923/ijcr.2011.267.277

URL: https://scialert.net/abstract/?doi=ijcr.2011.267.277

Related Articles

Anti-Angiogenic, Cytotoxic and Antimicrobial Activity of Plant Mediated Silver Nano Particle from Tragia involucrata
Preliminary Anticancer Screening and Standardization of some Indigenous Medicinal Plants using Cell-biology and Molecular Biotechnology Based Models
Evaluation of Enzymes Inhibition Activities of Medicinal Plant from Burkina Faso
Antifertility Activity of Hexane and Ethyl Acetate Extracts of Aerial Parts of Tragia involucrata. Linn
Antitumour Activity of Indigofera trita on Ehrlich Ascites Carcinoma Induced Mice
Chemical Composition, Cytotoxicity and Antioxidant Activity of Essential Oils of Acalypha hispida Flowers

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved