Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata


	International Journal of Cancer Research
	Year: 2011 \| Volume: 7 \| Issue: 4 \| Page No.: 267-277 DOI: 10.3923/ijcr.2011.267.277

Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata

Chandrashekhar G. Joshi, M. Gopal and N. Suchetha Kumari

Abstract: The practice of traditional medicines in treatment of cancer is based on the knowledge and use of plant based medicine since ancient time. The study of folk medicinal practices revealed the use of Tragia involucrata (Euphorbiaceae) along with other medicinal plants to treat certain tumours in some parts of Kerala, India. The aim of the present study was to evaluate the antitumor potential of hexane and ethyl acetate extracts (HE and EAE) and to asses the antioxidant activity of EAE of T. involucrata. The mice were injected with 10⁶ Ehrlich’s Ascites Carcinoma (EAC) cells subcutaneously and the extracts were administered intra-peritoneal (i.p.). In vitro antioxidant property of EAE was tested by 2, 2’-azinobis (3-ethylbenzo-thiozoline-6-sulphonic acid (ABTS)) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. In vivo antioxidant potential of EAE was determined by nitric-oxide by Griess-reagent method, total antioxidant in serum by phosphomolybdenum method and super oxide dismutase by nitroblue tetrazolium (NBT) method. Administration of the extracts to mice challenged with EAC showed significant antitumour activity. The observed antitumor activity of the extracts was dose dependant. There was a significant increase in the percentage life span (ILS %) in extract treated mice. HE was not toxic to mice even at the dose of 2000 mg kg^-1 body weight. EAE was toxic to animals when the dosage was increased beyond 150 mg kg^-1 . EAE was showing even a significant in vitro as well as in vivo antioxidant activity. In vivo antioxidant activity was showing the reciprocal dose response. From the results it may be concluded that the plant posses antitumor activity as claimed in traditional practices.

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How to cite this article:

Chandrashekhar G. Joshi, M. Gopal and N. Suchetha Kumari, 2011. Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata. International Journal of Cancer Research, 7: 267-277.

DOI: 10.3923/ijcr.2011.267.277

URL: https://scialert.net/abstract/?doi=ijcr.2011.267.277

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