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International Journal of Cancer Research
  Year: 2011 | Volume: 7 | Issue: 3 | Page No.: 244-253
DOI: 10.3923/ijcr.2011.244.253
 
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Evaluation of Anticancer Activity of Lagenaria siceraria Aerial Parts

P. Saha, S. Kundu Sen, A. Bala, U.K. Mazumder and P.K. Haldar

Abstract:
Cancer is one of the leading causes of mortality worldwide. Many of the cucurbitaceae plants possess antitumor activity. On the basis of traditional use, the present study was carried out to evaluate the anti-cancer activity of methanol extract of Lagenaria siceraria (Mol.) Standley [Cucurbitaceae] aerial parts (MELS) on Ehrlich’s Ascites Carcinoma (EAC) model in mice. After inoculation of EAC cells into mice, treatment with MELS (200 and 400 mg kg-1) and standard drug, 5-Fluorouracil (20 mg kg-1) were continued for 9 days. Evaluation of the effect of drug response was made by the study of tumor growth response including increase in life span, study of hematological parameters, biochemical estimations and antioxidant assay of liver tissue. Experimental results revealed that L. siceraria possesses significant anticancer activity which may be due to its cytotoxicity and antioxidant properties. Further research is ongoing to find out the bioactive principle(s) of MELS for its anticancer activity.
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How to cite this article:

P. Saha, S. Kundu Sen, A. Bala, U.K. Mazumder and P.K. Haldar, 2011. Evaluation of Anticancer Activity of Lagenaria siceraria Aerial Parts. International Journal of Cancer Research, 7: 244-253.

DOI: 10.3923/ijcr.2011.244.253

URL: https://scialert.net/abstract/?doi=ijcr.2011.244.253

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