Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Cancer Research
  Year: 2011 | Volume: 7 | Issue: 2 | Page No.: 135-143
DOI: 10.3923/ijcr.2011.135.143
Evaluation of Anticancer Activity of Macrosolen parasiticus (L.) Danser on Ehrlich's Ascites Carcinoma Treated Mice
V. Sodde, N. Dashora, K.S. Prabhu and R. Lobo

Abstract:
The present study was undertaken is to explore the anticancer activity of the methanolic and aqueous stem extract of the Macrosolen parasiticus in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line. The activity of ethanolic and aqueous extracts of Macrosolen parasiticus was evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 150 and 300 mg kg-1 body weight orally. Both extracts at both doses were administered for 13 consecutive days. Twenty four hours of last dose and eighteen hours of fasting, the mice were sacrificed and anti cancer effect of methanolic and aqueous extracts assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. The both the extracts showed significant decrease in (p<0.0001) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Haematological profile such as RBC, haemoglobin and WBC count reverted to normal level in treated mice. From the result it was demonstrated that the extract has potent dose dependent anticancer activity and that is comparable to that of cisplatin. Aqueous extract at both doses (150 and 300 mg kg-1) and methanolic extract at 300 mg kg-1 dose showed potent anticancer activity. Further investigation to explore the potential of the aqueous extracts of M. parasiticus in tumor treatment may prove to be worthwhile as a natural source of the drug.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Experimental Approach to Treatment of Colorectal Cancer by Herbs and Their Constituents: An Overview on in vivo and in vitro Protocols and Molecular Targets
  •    Numerical Simulation of Tumor Development Stages Using Artificial Neural Network
  •    Anti-tumor Activity of Some 1,3,4-thiadiazoles and 1,2,4-triazine Derivatives against Ehrlichs Ascites Carcinoma
  •    Antitumor Activity of Hexane and Ethyl Acetate Extracts of Tragia involucrata
  •    Antitumor Effect of Snake Venom (Hydrophis spiralis) on Ehrlich Ascites Carcinoma Bearing Mice
  •    DEN-Induced Cancer and its Alleviation by Anisomeles malabarica (L.) R.Br. Ethanolic Leaf Extract in Male Albino Mice
  •    Antitumour Activity of Indigofera trita on Ehrlich Ascites Carcinoma Induced Mice
  •    Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart
How to cite this article:

V. Sodde, N. Dashora, K.S. Prabhu and R. Lobo, 2011. Evaluation of Anticancer Activity of Macrosolen parasiticus (L.) Danser on Ehrlich's Ascites Carcinoma Treated Mice. International Journal of Cancer Research, 7: 135-143.

DOI: 10.3923/ijcr.2011.135.143

URL: https://scialert.net/abstract/?doi=ijcr.2011.135.143

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

       

       

Curve Bottom