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International Journal of Cancer Research

Year: 2011 | Volume: 7 | Issue: 2 | Page No.: 125-134
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Authors

P.C. Pereira

A.F. Vicente

M.F. Mesquita

A.S. Cabrita

Keywords

Research Article

The Role of Phaseolus vulgaris in DMBA-Induced Sprague-Dawley Rat Mammary Carcinomas

P.C. Pereira, A.F. Vicente, M.F. Mesquita and A.S. Cabrita
The present study intended to study the influence of Phaseolus vulgaris beans in mammary carcinogenesis especially considering the main malignancy indicators through a histopathology study. A total of 72 female rats 50 days old were divided in three groups and hold in constant conditions temperature, light and humidity. Group B and C received 20 mg of 7, 12 dimethyl benzanthracene by gavages. All the animals were fed with the same standard food, group C were supplemented with Phaseolus vulgaris beans. The study had last for 150 days. Tumors in group C animals had lower pattern grades and lower mitotic counts despite the higher weight gain in this group. These results suggest a protective role of bean consumption in mammary carcinogenesis possibly due to fiber and oligossacharides content, especially present in Phaseolus vulgaris from “padrão tarrestre” species.
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