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International Journal of Cancer Research

Year: 2009 | Volume: 5 | Issue: 4 | Page No.: 167-175
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Authors

R. Sunkara

M. Verghese

L. Shackelford

L.T. Walker

E. Cebert

Keywords

Research Article

Preventive Potential of Sorrel (Hibiscus sabdariffa) Calyx on the Formation of Azoxymethane Induced Aberrant Crypt Foci in Colon of Rats

R. Sunkara, M. Verghese, L. Shackelford, L.T. Walker and E. Cebert
The objective of this study was to determine the effects of dietary administration of sorrel calyx and sorrel juice on the induction and development of azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) in Fisher 344 rats. Thirty male F344 rats were randomly divided into 5 groups and fed AIN 93-G diet as control, AIN 93-G+sorrel meal (5 and 10%) or juice (2.5 and 5%). Rats were given subcutaneous injections of AOM (16 mg kg-1 b.wt.) once a week for 2 weeks and were killed after administering sorrel for 13 weeks. The effect of sorrel on detoxification (phase I and II) and antioxidant enzymes (catalase (CAT) and superoxide dismutase (SOD)) was also determined. Treatment with dietary sorrel meal and juice significantly (p<0.05) decreased total number of ACF and the total number of aberrant crypts compared to the control fed rats. Feeding sorrel meal at 10% level significantly (p<0.05) reduced the percentage of ACF by 70% compared to the control. Administration of sorrel to rats significantly (p<0.05) increased hepatic Glutathione-S-Transferase (GST), CAT and SOD activities by 3.3-6.5 fold compared to the control fed rats. However, no effect on CYP2E1 activity was observed among the treatment groups. Present results demonstrate the chemopreventive potential of sorrel either as meal or juice on AOM induced ACF as well as its ability to modulate detoxification and antioxidant enzymes.
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