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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 3 | Page No.: 92-102
DOI: 10.3923/ijcr.2008.92.102
 
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Role of Glutathione and Glutathione-Related Enzymes in the Antitumor Activity of Dillenia pentagyna in Dalton`s Lymphoma-Bearing Mice

G. Rosangkima, T. Rongpi and S.B. Prasad

Abstract:
The aim of present study was to determine the antitumor potential of D. pentagyna and the level of glutathione and glutathione-related enzyme activities (i.e., glutathione-s-transferase, glutathione reductase and glutathione peroxidase) in the host tissues in order to find their possible involvement in the antitumor activity of D. pentagyna. The most potent antitumor activity of methanol extract of D. pentagyna (%ILS~70) was observed at a dose of 20 mg kg-1 body wt. day-1. The present finding shows a significant D. pentagyna extract-mediated change in the level of GSH and GSH-related enzyme activities in different tissues at different interval of time. A significant decrease in the level of GSH, glutathione reductase and glutathione peroxidase activities were noted in DL cells after plant extract treatment (20 mg kg-1 body wt.). These findings suggest that the plant extract-mediated decrease of GSH, GR and GPx in DL cells may have a role in the antitumor activity of D. pentagyna by decreasing the protective ability of DL cells, thereby enhancing tumor cell death and increasing host survivability.
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How to cite this article:

G. Rosangkima, T. Rongpi and S.B. Prasad, 2008. Role of Glutathione and Glutathione-Related Enzymes in the Antitumor Activity of Dillenia pentagyna in Dalton`s Lymphoma-Bearing Mice. International Journal of Cancer Research, 4: 92-102.

DOI: 10.3923/ijcr.2008.92.102

URL: https://scialert.net/abstract/?doi=ijcr.2008.92.102

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