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International Journal of Cancer Research

Year: 2008 | Volume: 4 | Issue: 3 | Page No.: 71-80
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Authors

Kameswaran Ravichandran

Ravichandran Ramanibai

Keywords

Research Article

Protective Effect of Flavanoidal Fraction of Indigofera tinctoria on Benzo (α) Pyrene Induced Lung Carcinogenicity in Swiss Albino Mice

Kameswaran Ravichandran and Ravichandran Ramanibai
The chemopreventive effect of the flavanoidal fraction of Indigofera tinctoria were evaluated in Swiss albino mice using 16 week medium term model of benzo (a) pyrene (BP)-induced lung tumor. Lung tumor was induced biweekly through oral incubation of BP for 4 weeks. The oral administration of flavanoidal fraction of I. tinctoria (100 mg kg-1 body weight) showed a significant increase in antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT) and non enzymic antioxidants like reduced glutathione (GSH), vitamin C and vitamin E were significantly increased when compared to BP treated groups. The effect is much more pronounced in pretreatment regime than in the post treatment regime. The levels of lung marker enzymes were significantly decreased in both the treatment regimes when compared to cancer induced group. The levels of lipid peroxidation were significantly decreased in the flavanoidal fraction of I. tinctoria treated regimes. The elevated levels of glycoproteins were normalized in the animals subjected to flavanoidal fraction of I. tinctoria treatment. The histopathological studies confirmed the protective effect of the extract by showing the reappearance of alveolar spaces in the treatment regimes, where the effect is pronounced much in the pre treatment regime than the post treatment regime. From the results obtained it is concluded that flavanoidal fraction of I. tinctoria had protective effects on BP induced lung cancer.
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