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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 154-159
DOI: 10.3923/ijcr.2008.154.159
Anti-Tumor Activities of Analogues Derived from the Bioactive Compound of Zingiber zerumbet
S.I.A. Wahab, A.B. Abdul, H.C. Yee1, A.S. Alzubairi, M.M. Elhassan and M.M. Syam

Abstract:
The aim of this study is to evaluate some derivatives of Zerumbone for their anti-tumor effects towards human cervical cancer cell lines (HeLa). The MTT tetrazolium salt colorimetric assay was utilized to evaluate the cytotoxic effects of ZER, cisplatin and the derivatives were n-Butylbenzene (compound 5), 1,1`-(4-Chlorobutylidene) bis(4-fluorobenzene) (compound 6), alpha, alpha-Diphenyl-gamma-butyrolactone (compound 7) and (1,4`-Bipiperidine)-4`-carboxaminde (compound 8). The results of this study showed that derivatives of ZER have shown lesser anti-tumor effects towards HeLa cancer cells compared to the principal compound (ZER).
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How to cite this article:

S.I.A. Wahab, A.B. Abdul, H.C. Yee1, A.S. Alzubairi, M.M. Elhassan and M.M. Syam, 2008. Anti-Tumor Activities of Analogues Derived from the Bioactive Compound of Zingiber zerumbet. International Journal of Cancer Research, 4: 154-159.

DOI: 10.3923/ijcr.2008.154.159

URL: https://scialert.net/abstract/?doi=ijcr.2008.154.159

 
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