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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 137-145
DOI: 10.3923/ijcr.2008.137.145
 
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Genomic Distribution, Expression and Pathways of Cancer Metasignature Genes Through Knowledge Based Data Mining

Muhummadh Khan and Kaiser Jamil

Abstract:
In the present study, we tried to integrate information from various sources to understand the role of cancer metasignature genes in initiation and progression of neoplasia. We analyzed these cancer metasignature genes for their chromosomes distribution, expression profiles in normal human tissues and the cellular pathways in which they are involved using the relevant data from the biological databases. It is concluded that cancer metasignature genes are needed for proper functioning and maintenance of normal cellular physiology. We report that multiple numbers of these genes were involved in three cellular processes; cell division cycle, antigen processing and presentation and proteasome dependent proteolysis. They are also involved in a myriad of metabolic and genetic processes. We propose that it is possible that almost all cell types of the human body contain a dormant genetic network which enables them to overcome senescence or evade apoptosis. This network when activated due to some effective trigger may lead to cancer generation and progression.
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How to cite this article:

Muhummadh Khan and Kaiser Jamil, 2008. Genomic Distribution, Expression and Pathways of Cancer Metasignature Genes Through Knowledge Based Data Mining. International Journal of Cancer Research, 4: 137-145.

DOI: 10.3923/ijcr.2008.137.145

URL: https://scialert.net/abstract/?doi=ijcr.2008.137.145

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