
	International Journal of Cancer Research
	Year: 2007 \| Volume: 3 \| Issue: 3 \| Page No.: 134-142 DOI: 10.3923/ijcr.2007.134.142

In vivo Antimutagenic Potential of Ginger on Formation and Excretion of Urinary Mutagens in Rats

K. Nirmala, T. Prasanna Krishna and K. Polasa

Abstract: A link between diet and health has been appreciated by many cultures for centuries; however, an association between diet and cancer has been documented only in recent decades. The diet is likely the major source of human exposure to environmental carcinogens/mutagens and anticarcinogens/antimutagens. Spices and condiments that are important components of our diet are also used in traditional medicine to treat variety of ailments. Ginger has been used in Ayurveda to alleviate inflammation, pain associated with rheumatoid arthritis, osteoarthritis and muscular discomfort. Literature evidence suggests that some of the active constituents present in ginger show anticancer activity by inhibiting tumorigenicity in animal model following topical application/feeding. Agents having genotoxic property exhibit antimutagenic, antioxidant and anti-inflammatory properties. It was shown in an in vitro experiment using single cell gel electrophoresis that ginger could inhibit benzo(a)pyrene, a well known carcinogen, induced cell damage, suggesting that ginger has antimutagenic potential. In order to investigate if this effect could be present even under in vivo conditions, a study was planned to investigate antimutagenic potential of ginger. Ginger powder was incorporated in the diet and fed to NIN male Wistar rats. At the end of one month of ginger feeding the rats were injected with 5 mg of benzo(a)pyrene by intraperitoneal route(ip). Twenty-four hours urine was collected before and after carcinogen exposure. The urine samples were analyzed for urinary mutagens by Ames test. The results indicated the antimutagenic potential of ginger under in vivo conditions using the strains TA 98 and TA 100 strongly suggesting that regular intake of ginger through diet is likely to confer protective effect against carcinogen induced mutation events. Since dietary components are subjected to cooking before consumption, an in vitro experiment was designed to assess the antimutagenic potential of ginger subjected to heat treatment. The antimutagenic activity of ginger was retained even after boiling and frying indicating that ginger consumed through diet can confer protection against mutational events.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Potential of Ginger (Zingiber officinale) Rhizome and Watermelon (Citrullus lanatus) Seeds in Mitigating Aspartame-Induced Oxidative Stress in Rat Model

•	Turmeric Alleviates Benzo(a)pyrene Induced Genotoxicity in Rats: Micronuclei Formation in Bone Marrow Cells and DNA Damage in Tissues

•	In vitro Cytotoxic Activity of Dendrophthoe falcata on Human Breast Adenocarcinoma Cells-MCF-7

How to cite this article:

K. Nirmala, T. Prasanna Krishna and K. Polasa, 2007. In vivo Antimutagenic Potential of Ginger on Formation and Excretion of Urinary Mutagens in Rats. International Journal of Cancer Research, 3: 134-142.

DOI: 10.3923/ijcr.2007.134.142

URL: https://scialert.net/abstract/?doi=ijcr.2007.134.142

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		FSTA
		SCIMAGO

Science Alert