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International Journal of Cancer Research
  Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 127-133
DOI: 10.3923/ijcr.2007.127.133
 
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Comparison of Genetic Changes in Transitional and Squamous Bilharzial-Related Bladder Cancers Using Fluorescence in situ Hybridization

Ahmed A. Al-Qahtani and Magdy S. Aly

Abstract:
Two types of bladder cancer, Squamous Cell (SC) and Transitional Cell (TC) differ in their histopathology, clinical outcome and etiology. Therefore, the underlying genetic effects of these two types of tumor may also be different. We compared numerical aberrations of different chromosomes in bilharzial-associated squamous and transitional cell carcinoma of the bladder and correlated the findings to p53 gene amplification. Cystectomy for invasive bladder was performed in 35 men and 15 women with a mean age of 54.6 years (range 28 to 82). Of these patients 33% had histologically verified squamous cell carcinoma and 17% had transitional cell carcinoma. We used fluorescence in situ hybridization to evaluate the numerical aberrations of chromosomes 7, 9 and 17 and alterations in p53. Present results demonstrated that aberrations of chromosome 7 were observed in 75% of the squamous cell carcinoma and in 93% of transitional cell carcinoma. Aberrations of chromosome 9 were also observed in 90% of squamous cell carcinoma, however, they were seen only in 51% of transitional cell carcinoma. Aberrations of chromosome 17 were detected in only 25% of squamous cell carcinoma, compared to 82% in transitional cell carcinoma. The p53 gene amplification was similar in both types with 84% for squamous cell carcinoma and 73% for transitional cell carcinoma. Our data clearly show difference between chromosomal patterns of invasive bilharzial squamous cell carcinoma and transitional cell carcinoma. However, overexpression of p53 in both types was similar. Additionally, aberrations of chromosome 9 were observed in both types, which confirm the 2 pathways in the oncogenesis of squamous cell and transitional cell carcinoma.
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How to cite this article:

Ahmed A. Al-Qahtani and Magdy S. Aly, 2007. Comparison of Genetic Changes in Transitional and Squamous Bilharzial-Related Bladder Cancers Using Fluorescence in situ Hybridization. International Journal of Cancer Research, 3: 127-133.

DOI: 10.3923/ijcr.2007.127.133

URL: https://scialert.net/abstract/?doi=ijcr.2007.127.133

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