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International Journal of Cancer Research

Year: 2006 | Volume: 2 | Issue: 1 | Page No.: 47-49
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Authors

Asmah Rahmat

Susi Edrini

Abdah Md. Akim

Patimah Ismail

Taufiq Yap Yun Hin

Mohd Fadzelly Abu Bakar

Keywords

The antiproliferative activities of Strobilanthes crispus was evaluated using (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazoliumbromide) (MTT) assay against several cancer cell lines and Chang liver (normal) cell lines. The methanolic extracts of Strobilanthes crispus displayed the strongest cytotoxic effect on colon cancer (Caco-2) followed by human breast cancer hormone non-dependent (MDA-MB-231) and liver cancer (HepG-2) with IC50 values of 22.3, 27.2 and 29.3 μg mL-1, respectively. The chloroform extract of this plant was shown to also have cytotoxic effect against Caco-2 and HepG-2 with IC50 values of 25.1 and 28.0 μg mL-1, respectively. β-sitosterol and stigmasterol were isolated from the leaves of Strobilanthes crispus. β-sitosterol displayed cytotoxic properties against Caco-2, HepG-2 and MCF-7 with IC50 values of 20.0, 53.0 and 71.2 μM, respectively. Whereas, stigmasterol inhibited the proliferation of Caco2, HepG2, MCF-7 and MDA-MB-231 with IC50 values of 132.5, 182.5, 156.0 and 185.9 μM, respectively. There was no cytotoxic effect observed on normal cell lines (Chang liver) in all samples tested.
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