Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Cancer Research
  Year: 2006 | Volume: 2 | Issue: 4 | Page No.: 376-382
DOI: 10.3923/ijcr.2006.376.382
Zinc Inhibits Tumor Metastasis by Regulating Plasminogen Activation
Zhigang Tu and Jun F. Liang

Abstract:
In this study, we found that zinc exerted a dual inhibition effect on plasminogen activator/plasmin system by inhibiting plasminogen activator activation and down-regulating plasmin activity. Zinc demonstrated significant inhibition effects on plasminogen activator and plasmin induced cell morphology change and movement. These results explain the anti-tumor and metastasis blocking effects of zinc observed in clinical studies. In addition, the strong down-regulation effects of zinc on plasminogen activator/plasmin system also suggest the potential role of zinc in other fibrinolysis associated diseases including neurodegenerative diseases.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Zhigang Tu and Jun F. Liang , 2006. Zinc Inhibits Tumor Metastasis by Regulating Plasminogen Activation. International Journal of Cancer Research, 2: 376-382.

DOI: 10.3923/ijcr.2006.376.382

URL: https://scialert.net/abstract/?doi=ijcr.2006.376.382

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

       

       

Curve Bottom