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International Journal of Cancer Research
  Year: 2006 | Volume: 2 | Issue: 4 | Page No.: 376-382
DOI: 10.3923/ijcr.2006.376.382
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Zinc Inhibits Tumor Metastasis by Regulating Plasminogen Activation
Zhigang Tu and Jun F. Liang

In this study, we found that zinc exerted a dual inhibition effect on plasminogen activator/plasmin system by inhibiting plasminogen activator activation and down-regulating plasmin activity. Zinc demonstrated significant inhibition effects on plasminogen activator and plasmin induced cell morphology change and movement. These results explain the anti-tumor and metastasis blocking effects of zinc observed in clinical studies. In addition, the strong down-regulation effects of zinc on plasminogen activator/plasmin system also suggest the potential role of zinc in other fibrinolysis associated diseases including neurodegenerative diseases.
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How to cite this article:

Zhigang Tu and Jun F. Liang , 2006. Zinc Inhibits Tumor Metastasis by Regulating Plasminogen Activation. International Journal of Cancer Research, 2: 376-382.

DOI: 10.3923/ijcr.2006.376.382








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