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International Journal of Cancer Research
  Year: 2006 | Volume: 2 | Issue: 2 | Page No.: 131-142
DOI: 10.3923/ijcr.2006.131.142
Mitoxantrone, Ara-C and Pentostatin (Map Regimen): Phase I Study of a Novel Non-myeloablative Conditioning Regimen for Hematological Malignancies
Delong Liu , Karen Seiter , J.W. Chiao , Qiuhu Shi , Anila Qureshi , Woondoon Jeong Lulu Lu , John Nelson and Tauseef Ahmed

Abstract:
We studied a new combination of mitoxantrone, ara C and pentostatin (MAP) as non-myeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation (NST). 25 patients with high-risk hematological malignancies were enrolled in this phase I study. Median age was 51 years (26-62). The MAP regimen consists of mitoxantrone (40 mg m-2 on day -6), cytarabine (2 g m-2 on day -6,-5,-4) and pentostatin. Pentostatin was given from 6 to 13 mg m-2 over 2 or 3 days in a dose-escalating manner. 18 patients received HLA-matched sibling grafts, 7 patients received unrelated grafts. Median donor chimerism at 1 month was 76% for related NST, 98% at 3 months. Four of seven patients with unrelated NST had primary graft failure but all had autologous recovery, the other three had full donor chimerism. Day 100 mortality is 8%. Dose-limiting toxicity was not observed, but two patients enrolled at level 5 died of sepsis and severe GVHD, respectively. Level 4 (pentostatin 13 mg m-2 over 3 days) is safe and chosen as phase II regimen. With a median follow-up of 28 months (12-1122 days), the median duration of overall and disease-free survival are 15 and 12 months, respectively. The estimated disease-free and overall survival rates at 2 years are 37 and 40%, respectively. In conclusion, Level 4 of the MAP regimen is safe and chosen as phase II regimen for further clinical investigation.
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How to cite this article:

Delong Liu , Karen Seiter , J.W. Chiao , Qiuhu Shi , Anila Qureshi , Woondoon Jeong Lulu Lu , John Nelson and Tauseef Ahmed , 2006. Mitoxantrone, Ara-C and Pentostatin (Map Regimen): Phase I Study of a Novel Non-myeloablative Conditioning Regimen for Hematological Malignancies. International Journal of Cancer Research, 2: 131-142.

DOI: 10.3923/ijcr.2006.131.142

URL: https://scialert.net/abstract/?doi=ijcr.2006.131.142

 
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