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International Journal of Cancer Research

Year: 2005 | Volume: 1 | Issue: 1 | Page No.: 53-56
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Authors

A. Avci

M. Kacmaz

M. Kavutcu

E. Gocmen

I. Durak

Keywords

Research Article

Effects of an Antioxidant Extract on Adenosine Deaminase Activities in Cancerous Human Liver Tissues

A. Avci, M. Kacmaz, M. Kavutcu, E. Gocmen and I. Durak
Effects of an antioxidant extract consisting mainly of garlic (Allium sativum) and red clover (Trifolium pratense) on adenosine deaminase (ADA) activities were investigated in cancerous and non cancerous human liver tissues and, results were compared with those of fludarabine. Ten cancerous and 10 non cancerous adjacent liver tissues were obtained from patients with metastatic type liver cancer by surgical operations. Kinetic analyses were carried out to establish Vmax and Km values of the reaction catalyzed by ADA under normal and inhibitor conditions. ADA activity was found lower in the cancerous tissues compared with non cancerous ones. Antioxidant extract created significant inhibitions on the ADA activities both in cancerous and non cancerous tissues. Inhibition percents were relatively higher in the cancerous tissues as compared with non cancerous ones. Furthermore, we have observed that inhibition percents created by the extract are higher than those of fludarabine at the concentrations studied. Results suggest that antioxidant extract exerts significant inhibition on the ADA activity in cancerous and non-cancerous human liver tissues. This might be rational basis for the use of these herbs in the alternative cancer therapy in the folk medicine.
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Comments

Hemalatha Sivaraman Reply

Sir,
I am not clear with method used in assay of garlic and red clove activity in cancerous tissues.sir can you send detailed methods used in this process.thank you sir for such nice paper.

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