• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Biological Chemistry
  2. Vol 8 (2), 2014
  3. 91-99
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Biological Chemistry

Year: 2014 | Volume: 8 | Issue: 2 | Page No.: 91-99

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 447

Search


Authors


V. Manigandan

Country: India

S. Gurudeeban

Country: India

K. Satyavani

Country: India

T. Ramanathan

Country: India

Keywords


  • neuro-inflammation
  • COX2
  • Ajmalicine
  • auto dock
  • amino acid
  • binding energy
Short Communication

Molecular Docking Studies of Rhizophora mucronata Alkaloids Against Neuroinflammatory Marker Cyclooxygenase 2

V. Manigandan, S. Gurudeeban, K. Satyavani and T. Ramanathan
Computer aided drug design is playing an important role in identifying the drug targets. The contribution of cyclooxygenase-2 (COX-2) to peripheral inflammation and brain inflammation is well documented. Therefore, the present study aimed to evaluate inhibitory effect of Rhizophora mucronata derived alkaloids such as ajmalicine, vindoline, catharanthine, serpentine and tabersonin on COX 2. Based on Lamarckian genetic algorithm, the alkaloids were docked with target protein using Auto Dock 4.0. The results indicated serpentine and ajmalicine expresses higher binding energy (-9.16 and -8.12 kcal mol-1), length of a hydrogen bond (2.211 and 2.079), amino acid residues (HIS 388) on cyclooxygenase 2 receptor than compared to other derivatives. This study concludes that serpentine and ajmalicine acts as a potent source for anti-neuro-inflammatory agents. Further preclinical studies will be carried out to find out the exact molecular level mechanism and drug development for neuro inflammation disorders.
PDF Fulltext XML References Citation

How to cite this article

V. Manigandan, S. Gurudeeban, K. Satyavani and T. Ramanathan, 2014. Molecular Docking Studies of Rhizophora mucronata Alkaloids Against Neuroinflammatory Marker Cyclooxygenase 2. International Journal of Biological Chemistry, 8: 91-99.

URL: https://scialert.net/abstract/?doi=ijbc.2014.91.99

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved