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International Journal of Biological Chemistry
  Year: 2014 | Volume: 8 | Issue: 1 | Page No.: 48-57
DOI: 10.17311/ijbc.2014.48.57
 
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Toxicological Evaluation of Melocia corchorifolia Leaves (L.) Fed to Albino Rat

K.J. Umar, L.G. Hassan, S.M. Dangoggo, S.A. Maigandi, N.A. Sani and A.I. Dogonyaro

Abstract:
Wild leafy vegetables are widely eaten in developing countries and serves as nutrient supplements. The present study examined the effect of feeding albino rats with 75% Melocia corchorifolia leaves with respect to their body weight, liver and kidney biochemical, haematological and histological response. Results showed that the rats fed with M. corchorifolia leaves experience decrease in body weight compared to the control group. The Packed Cell Volume (PCV), haemoglobin concentration (Hb) and Red Blood Cells (RBC), White Blood Cells (WBC), platelets, Mean Carpuscular Volume (MCV), Mean Carpuseular Haemoglobin (MCH), Mean Carpuscular Haemoglobin Concentration (MCHC) and leukocyte (lymphocyte, neutophils, monocytes, eosinophils and basophils) differential counts were not significantly (p>0.05) different between control and treatment. Similarly, serum total protein, globulin and bilirubin were not significantly different, but that of albumin was significantly lower (p<0.05) in the treatment than control group. The serum enzyme activities, i.e., aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) were significantly (p<0.05) elevated in sample treatment than the control; which is an indication of organ toxicity by cellular destruction induced by the phyto-toxin present in the fed. Renal function indices-serum creatinine, urea, uric acid and electrolytes were not significantly different (p>0.05) between control and treatment. The results of this study showed that Melocia corchorifolia leaves have a relatively low or no toxicity profile.
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How to cite this article:

K.J. Umar, L.G. Hassan, S.M. Dangoggo, S.A. Maigandi, N.A. Sani and A.I. Dogonyaro, 2014. Toxicological Evaluation of Melocia corchorifolia Leaves (L.) Fed to Albino Rat. International Journal of Biological Chemistry, 8: 48-57.

DOI: 10.17311/ijbc.2014.48.57

URL: https://scialert.net/abstract/?doi=ijbc.2014.48.57

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