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International Journal of Biological Chemistry

Year: 2013 | Volume: 7 | Issue: 1 | Page No.: 15-26
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Authors

Akbar Idhayadhulla

Radhakrishnan Surendra Kumar

Abdul Jamal Abdul Nasser

Aseer Manilal

Keywords

The compounds of 2,2'-[(3,5-dimethyl-1H-pyrrole-2,4-diyl) dicarbonyl]dihydrazine carboxamide(2), 2,2’-[(3,5-dimethyl-1H-pyrrole-2,4-diyl)dicarbonyl]dihydrazine carbothioamide(3), 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazine carboxamide(5) and 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine -3,5-diyl]dicarbonyl}dihydrazine carbothioamide (6) were synthesized from hydrazinolysis method and synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds were screened for antimicrobial and anticancer activities. Evaluation of antibacterial, antifungal activity showed that the compounds exhibited better results than reference drugs. The newly synthesized compounds have been screened for preliminary anticancer activity against HepG2(Liver), Hela(Cervical), MCF-7(Breast) cancer cells. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
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How to cite this article

Akbar Idhayadhulla, Radhakrishnan Surendra Kumar, Abdul Jamal Abdul Nasser and Aseer Manilal, 2013. Synthesis of Some New Pyrrole and Pyridine Derivatives and their Antimicrobial, Anticancer Activities. International Journal of Biological Chemistry, 7: 15-26.

URL: https://scialert.net/abstract/?doi=ijbc.2013.15.26

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