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International Journal of Biological Chemistry
  Year: 2009 | Volume: 3 | Issue: 4 | Page No.: 132-141
DOI: 10.3923/ijbc.2009.132.141
 
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Interaction Between Ascorbic Acid and Dopamine D2 Receptor in the Nucleus Accumbens Shell in Response to Feeding

F. Badreh, M. Abbasnejad, A. Derakhshani and H. Jonaidi

Abstract:
The aim of the present study is to evaluate the effects of intra-accumbens administration of Ascorbic Acid (AA) and co-administration of D2 agonist, bromocriptine (Br) and the D2 antagonist sulpiride (Su) (8, 16 μg rat-1) with AA on feed intake in adult male rats. The rats (220-300 g ) were divided into several groups for intra-accumbens injections: control (intact), sham AA (injected vehicle of ascorbic acid), ascorbic acid (10, 50, 250 μg rat-1), sham Br (injected vehicle of bromocriptine), bromocriptine (12.5, 25, 50 μg rat-1), sham Su (injected vehicle of sulpiride), sulpiride (4 and 16 μg rat-1), AA (50 μg rat-1) + Br (50 μg rat-1) and AA (50 μg rat-1) + Su (16 μg rat-1). After stereotaxic operation and passing one week recovery period, drugs were injected daily (volume = 1 μL) for four days. The intra-accumbens administration of ascorbic acid (10, 50, 250 μg rat-1) decreased feed intake. Intra-accumbens injection of D2 agonist bromocriptine (25, 50 μg rat-1) decreased feed intake. Co-administration of the AA (50 μg rat-1) also decreased feed intake. Administration of D2 antagonist sulpiride (8, 16 μg rat-1) increased food intake and co-administration of AA (50 μg rat-1) blocked this effect. These results suggest that AA can act within the Acb to decreases feed intake and it has an agonistic effect on feeding regulatory effects of D2 receptor.
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How to cite this article:

F. Badreh, M. Abbasnejad, A. Derakhshani and H. Jonaidi, 2009. Interaction Between Ascorbic Acid and Dopamine D2 Receptor in the Nucleus Accumbens Shell in Response to Feeding. International Journal of Biological Chemistry, 3: 132-141.

DOI: 10.3923/ijbc.2009.132.141

URL: https://scialert.net/abstract/?doi=ijbc.2009.132.141

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