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International Journal of Biological Chemistry
  Year: 2007 | Volume: 1 | Issue: 4 | Page No.: 205-212
DOI: 10.3923/ijbc.2007.205.212
 
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Evaluation of Hypoglycemic and Hypolipidemic Activity of Methanolic Extract of Cocculus hirsutus (L.) Diels Leaves in Streptozotocin-Induced Diabetes Mellitus Rats

P. Palsamy and R. Malathi

Abstract:
The aim of this study was to investigate the hypoglycemic and hypolipidemic activity of methanolic extract of Cocculus hirsutus (L.) Diels leaves in streptozotocin-induced diabetes mellitus rats and the effect of the extract was compared with glibenclamide, a standard hypoglycemic drug. The plant extract (CLEt) was administered orally (500 mg kg-1 body weight) and the effect of CLEt was estimated on the levels of hemoglobin, glycosylated hemoglobin, glucose, insulin, glucose-6-phosphatase, lipid peroxidation, triglycerides, cholesterol and phospholipids, in the plasma of STZ-induced (65 mg kg-1 body weight) diabetic rats. The plasma lipoproteins levels were also measured. STZ-induced diabetic rats showed significant (p<0.05) increase in the levels of glycosylated hemoglobin, glucose, glucose-6-phosphatase, cholesterol, phospholipids, triglycerides and lipid peroxidation and significant (p<0.05) decrease in insulin, hemoglobin, which were considerably restored to near normal in CLEt or glibenclamide treatment rats. The plasma lipoproteins (HDL-cholesterol and LDL-cholesterol) were altered significantly (p<0.05) in STZ-induced diabetic rats and these levels were also restored back to near normal by CLEt or glibenclamide treatment. These results suggest that CLEt possess an antidiabetic principle and may be useful for diabetes treatment.
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How to cite this article:

P. Palsamy and R. Malathi , 2007. Evaluation of Hypoglycemic and Hypolipidemic Activity of Methanolic Extract of Cocculus hirsutus (L.) Diels Leaves in Streptozotocin-Induced Diabetes Mellitus Rats. International Journal of Biological Chemistry, 1: 205-212.

DOI: 10.3923/ijbc.2007.205.212

URL: https://scialert.net/abstract/?doi=ijbc.2007.205.212

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