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International Journal of Biological Chemistry
  Year: 2007 | Volume: 1 | Issue: 3 | Page No.: 162-167
DOI: 10.3923/ijbc.2007.162.167
Studies on the Use of Tea Leaves as Pharmaceutical Adsorbent
Neelam Seedher and Karamvir Sidhu

In the present research an attempt has been made to explore the possibility of using tea leaves as pharmaceutical adsorbent. Adsorption of cefotaxime sodium (CS), paracetamol (Para), caffeine (Caf), Chlorpromazine hydrochloride (Cpz) and metronidazole (Metro) on tea leaves has been studied under different experimental conditions. The maximum adsorption capacity was observed for chlorpromazine HCl and cefotaxime sodium followed by caffeine and paracetamol. Least adsorption capacity was observed for metronidazole. It is seen that 179-457 mg of various drugs could be adsorbed per gram tea leaves at 25°C and pH 7.4. Adsorption data was found to obey both Langmuir and Freundlich adsorption isotherms. The adsorption capacity of all the drugs increased with increase in pH indicating thereby that negatively charged and neutral species are preferentially adsorbed by tea leaves as the pH is increased. At the highest pH used, 181-631 mg of drugs could be adsorbed per g tea leaves. The adsorption was fairly rapid, 80-90% of adsorption occurred in the first 3-4 h in most cases. The amount adsorbed decreased with increase in temperature in each case and the enthalpy of adsorption was found to be in the range -8.732 to -11.765 kJ mol-1. The weight of tea leaves required per dose for the commonly used doses of these drugs was also calculated. Tea leaves were found to be good adsorbents for these drugs and the data can be explored for the design of drug delivery systems as well as use of tea leaves as safe, natural and effective antidote for these drugs. The results were specially significant in the case of antipsychotic drug, chlorpromazine hydrochloride, where only 0.06 g tea leaves are required per dose and therefore, tea leaves are an excellent adsorbent for this drug. The present study leads to an important conclusion that tea leaves have the potential to be used as a safe and effective pharmaceutical adsorbent for the studied drugs.
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How to cite this article:

Neelam Seedher and Karamvir Sidhu , 2007. Studies on the Use of Tea Leaves as Pharmaceutical Adsorbent. International Journal of Biological Chemistry, 1: 162-167.

DOI: 10.3923/ijbc.2007.162.167






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