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International Journal of Biological Chemistry
  Year: 2007 | Volume: 1 | Issue: 3 | Page No.: 156-161
DOI: 10.3923/ijbc.2007.156.161
Effect of Vitamin E on Ethanol-induced Increase in Some Cardiovascular Parameters and Blood Uric Acid Levels in Man
I. Onyesom , U.E. Uzuegbu , E.K. Nwangwa , G.E. Umukoro and I.R. Aninyei

Abstract:
Alcohol metabolism has been reported to generate Reactive Oxygen Species (ROS) which initiate series of oxidative reactions that culminate in hyperuricemia and accompanying cardiovascular dysfunction. Present study investigates the effect of a free radical scavenger-vitamin E, on alcohol-induced increase in serum uric acid, triacylglycerol and blood pressure. One hundred consenting undergraduates (60 males and 40 females) in apparent good health and who were matched in age, weight and body build were selected and tested on four different occasions separated by 14 days. On the first day of testing, the subjects were randomly separated into Groups A (0.75 mL fruit juice/kg + 100 mg tapioka dried cassava product: n = 25), Group B (0.75 ml ethanol/kg+ 100 mg tapioka: n = 25), Group C (0.75 mL ethanol/kg + 100 mg vitamin E:n = 25) and Group D (0.75 mL fruit juice/kg + 100 mg vitamin E: n = 25) and were treated as indicated. The ethanol administered was diluted to 30% with fruit juice. Each participant was rotated every forthnight until he/she completes the four rounds of testing. The data obtained show that the co-administration of ethanol and vitamin E significantly reduced (p<0.05) the level of serum uric acid and the proportion of subjects in the prehypertension and stage 1 hypertension classes induced by ethanol consumption alone. Apart from confirming the recent proposal that links ROS to hyperuricemia and secondary cardiovascular disorders, this study suggests that boosting the level of antioxidant vitamins in the body could alleviate the ethanol-induced hyperuricemia and perhaps, associated disease conditions.
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How to cite this article:

I. Onyesom , U.E. Uzuegbu , E.K. Nwangwa , G.E. Umukoro and I.R. Aninyei , 2007. Effect of Vitamin E on Ethanol-induced Increase in Some Cardiovascular Parameters and Blood Uric Acid Levels in Man. International Journal of Biological Chemistry, 1: 156-161.

DOI: 10.3923/ijbc.2007.156.161

URL: https://scialert.net/abstract/?doi=ijbc.2007.156.161

 
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