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International Journal of Botany
  Year: 2020 | Volume: 16 | Issue: 2 | Page No.: 58-64
DOI: 10.3923/ijb.2020.58.64
 
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Biological Activities of Supercritical Carbon Dioxide Extract of Parkia speciosa Seeds and Pods

Ka Lun Wong, Chun Hoe Tan, Kae Shin Sim and Yun Jin Kim

Abstract:
Backgrounds and Objective: Parkia speciosa (petai) is popular as a culinary ingredient and folk medicine in treating various ailments. The extraction of novel bioactive components from plant-based natural products is crucial to meet global health needs. Nonetheless, the biological activities of plant extracts usually show a significant variation depending on the extraction methods. In this study, Supercritical Carbon Dioxide (SCD) extraction was performed on P. speciosa seeds and pods, and their biological activities were investigated. Materials and Methods: P. speciosa seed (SE) and pod (PE) extracts were obtained by SCD extraction method using a Waters’ Supercritical Fluid Extraction System. The radical scavenging ability of the extracts was tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+) radical scavenging assays, and their cytotoxicity was screened using MTT assay inclusive of seven human cancer cell lines. The relationship between the results of the assays was measured in pairwise using Pearson’s correlation. Results: Both PE and SE exhibited considerable DPPH and ABTS+ radical scavenging activities in a dose-dependent manner. PE exhibited pronounced cytotoxicity against human colorectal carcinoma HCT 116 (IC50 0.54±0.14 μg mL1) and the activity is comparable with the common chemotherapeutic cisplatin (IC50 0.73±0.26 μg mL1). Pearson’s correlation indicates that there is no significant correlation between the radical scavenging activity and cytotoxicity of PE. Conclusion: Our findings implied that PE and SE obtained using SCD extraction exhibited considerable antioxidant activity, and only PE showed potent cytotoxicity which may be developed further to contribute to the management of colorectal cancer.
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How to cite this article:

Ka Lun Wong, Chun Hoe Tan, Kae Shin Sim and Yun Jin Kim, 2020. Biological Activities of Supercritical Carbon Dioxide Extract of Parkia speciosa Seeds and Pods. International Journal of Botany, 16: 58-64.

DOI: 10.3923/ijb.2020.58.64

URL: https://scialert.net/abstract/?doi=ijb.2020.58.64

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