Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Botany
  Year: 2015 | Volume: 11 | Issue: 1 | Page No.: 21-26
DOI: 10.3923/ijb.2015.21.26
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Inhibitory Potential of Terminalia chebula by Hydrogen Peroxide Induced Oxidative Stress in THP-1 Cell Line

G.C. Minakshi, K. Vasanth, Tanupriya , K. Ilango, Aruna Agrawal and G.P. Dubey

Abstract:
Diseases caused due to ‘oxidative stress’ initiated by Reactive Oxygen Species (ROS) is growing at an alarming rate. Several medicinal herbs explored till date were reported to possess numerous pharmacological properties used for combating different diseases. The present study was undertaken to investigate the inhibitory potential of Terminalia chebula by H2O2 induced oxidative stress in THP-1 cell line and also the presence of the marker compounds in T. chebula was confirmed by High Performance Liquid Chromatography (HPLC). Intracellular quantification of ROS was done using a flow cytometer. The percentage of gallic acid and ellagic acid in the extract was performed by HPLC were found to be 4.84% w/w and 2.56% w/w, respectively. Pretreatment of cells with T. chebula extract significantly reduced the intracellular ROS production in a dose-dependent manner. The present study illustrates the effective role of T. chebula in reducing the ROS production which is a causative factor for several disorders. The results describe the possibility and potentiality of natural sources to inhibit the pathogenesis of different diseases caused due to oxidative stress.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

G.C. Minakshi, K. Vasanth, Tanupriya , K. Ilango, Aruna Agrawal and G.P. Dubey, 2015. Inhibitory Potential of Terminalia chebula by Hydrogen Peroxide Induced Oxidative Stress in THP-1 Cell Line. International Journal of Botany, 11: 21-26.

DOI: 10.3923/ijb.2015.21.26

URL: https://scialert.net/abstract/?doi=ijb.2015.21.26

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

Curve Bottom