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Current Research in Neuroscience

Year: 2016 | Volume: 6 | Issue: 1 | Page No.: 1-15
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Authors

Souravh Bais

Souravh Bais

Renu Kumari

Yash Prashar

Yash Prashar

Keywords

Review Article

A Review on Current Strategies and Future Perspective in Respect to Alzheimer’s Disease Treatment

Souravh Bais Souravh Bais's LiveDNA, Renu Kumari and Yash Prashar Yash Prashar's LiveDNA
Alzheimer’s Disease (AD) is the most common cause of dementia worldwide, characterized as a progressive and irreversible neurodegenerative disease. It is probably caused by complex interactions among multiple genetic, epigenetic and environmental factors. The pathophysiology of AD is largely represented by the neurotoxic events triggered by the proteins like β-amyloid cascade and the hyper phosphorylation of microtubule associated tau proteins and other copathogens in neurons. These processes lead respectively to the formation of neurotic plaques and neurofibrillary tangles which are the pathological hallmarks of the disease. Last 20 years extensive study was done to search (through the internet, books, journals and software’s) available data to elaborate the current update on Alzheimer’s disease. The available data related to etiology, pathophysiology, molecular pathway, traditional cure and available treatment of AD were discussed throughout this study. This study will provide an enough data to various academicians regarding current pharmacological, non-pharmacological interventions, ethnopharmacological treatments and other relevant data related to AD. Due to in availability of proper cure for this disorder and much of the treatment available has been able only delay the progression of the disease or provide symptomatic relief for a short period of time. So much more targeted approach should be discovered to resolve the complications. Arise due to tau proteins and further study on amyloids in underway.
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