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Current Research in Neuroscience
  Year: 2012 | Volume: 2 | Issue: 1 | Page No.: 1-10
DOI: 10.3923/crn.2012.1.10
Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration
A.J. Ajibade, P.B. Fakunle and P.D. Shallie

Abstract:
Several neurological disorders following abuse of artesunate used in chloroquine resistant malarial cases have been reported but little attention has been given the effects of this drug on histology of cerebellar cortex and Nissl substances. Twenty-four adult wistar rats of both sexes weighing between 150 and 230 g were randomly separated into four groups, N = 6. Rats in group D (control), received distilled water throughout exposure period while groups A, B and C (experimental groups) received 4 mg kg-1 b.wt. of artesunate orally on treatment day 1. Group A continued with (4 mg kg-1 b.wt.) for the next 3 days while group B and C received 2 mg kg-1 b.wt. of artesunate orally for the next 6 and 13 days, respectively. Groups A, B and C rats were sacrificed respectively on 5th, 8th and 15th day of treatment while Group D rats were sacrificed on the 15th day. Cerebellum of each rat was carefully dissected out and fixed in 10% formal saline for routine histological techniques. Histological findings showed normal cortical layers in control rats compared with degenerated and loss of purkinje cells, cellular hypertrophy with intercellular vacuolation appearing in the stroma of cerebellar cortex of treated rats. Nissl substances in cerebellar cortex of treated rats stained less intensely and appeared degenerated compared to more intensely stained and distinctly distributed Nissl substances in control rats. The observed vacuolation and neuronal loss in the cortical layers of the treated rats may adversely affect cerebellar functions while less intensely stained and degenerative changes in the Nissl substances in the cerebellar cortex of the treated rats may adversely affect protein synthesis in relation to neuronal functions.
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How to cite this article:

A.J. Ajibade, P.B. Fakunle and P.D. Shallie, 2012. Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration. Current Research in Neuroscience, 2: 1-10.

DOI: 10.3923/crn.2012.1.10

URL: https://scialert.net/abstract/?doi=crn.2012.1.10

 
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