Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Current Research in Cardiovascular Pharmacology
  Year: 2012 | Volume: 1 | Issue: 1 | Page No.: 1-9
DOI: 10.3923/crcpaj.2012.1.9
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Some Morphological Findings on the Heart of Adult Wistar Rats Following Experimental Artesunate Administration

A.J. Ajibade, P.B. Fakunle, M.O. Adewusi and O.O. Oyewo

Abstract:
There has been increasing reports of ischemic cardiac disease which may be attributed to cardiovascular risk factor as well as adverse effects of some drugs. This study assessed the effect of oral artesunate on the heart morphology. Twenty-four adult wistar rats weighing between 150 and 230 g were separated into four groups, each containing six rats. Group A rats received distilled water while Group C, B and D received 4 mg kg-1 body weight of artesunate orally on day one of the treatment. Group A continued with the same dose for the next 3 days of the treatment. Rats in group B and C received 2 mg kg-1 body weight of artesunate orally for the next 6 and 13 days, respectively. The treated rats in group B, C and D were sacrificed, respectively on 5th, 8th and 15th day of the treatment. The control rats were sacrificed on the 15th day. The heart of each rat was removed and weighed before fixing in 10% formal saline for histological procedures. Results showed normal histological features in control while the treated rats revealed distortions, disaggregation, vacuolation and degenerative changes in cardiac tissue. The heart weight increased significantly (p<0.05) from mean value of 0.41±0.02 in group A to 0.48±0.02 in group B, 0.49±0.03 and 0.57±0.04 g in group C and D, respectively. The observed, distortions, disaggregation, vacuolations and increased heart weight in the treatment groups may impair cardiovascular function and predispose to cardiovascular disorder.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Examination of Cardiovascular Toxicity and Trace Elements Status in Albino Rats Treated with Okposi and Uburu Salt Lakes (Nigeria)
  •    Histopathological Observations on Protective Effects of Vitamin E on Endosulfan Induced Cardiotoxicity in Rats

  •    Histopathological Effect of Enalapril Maleate on Fetal Heart in Rat
  •    Biological and Toxicological Effects of Aqueous Acetone Extract of Cienfuegosia digitata Cav. (Malvaceae) in Mice and Rats
How to cite this article:

A.J. Ajibade, P.B. Fakunle, M.O. Adewusi and O.O. Oyewo, 2012. Some Morphological Findings on the Heart of Adult Wistar Rats Following Experimental Artesunate Administration. Current Research in Cardiovascular Pharmacology, 1: 1-9.

DOI: 10.3923/crcpaj.2012.1.9

URL: https://scialert.net/abstract/?doi=crcpaj.2012.1.9

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 

Curve Bottom