Abstract:
The 2,4,5-triphenylimidazole was synthesized by refluxing benzoin, benzaldehyde
and ammonium acetate in equimolar quantities. The Mannich bases were synthesized
by using abstractable hydrogen present in 2,4,5-triphenylimidazole because various
drugs obtained from Mannich reaction have proved more effective and less toxic
than their parent drugs. Various Mannich Bases of 2,4,5-triphenylimidazole i.e.,
5(a); 5-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole,5(b);5-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole,
5(c); 3-(2,4,5-triphenyl-1H-imidazol-1-yl) methyl)morpholine, 5(d); N,N-dimethy
l(2,4,5-triphenyl-1H-imidazol-1-yl)methanamine, 5(e); N-ethyl-N-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)
ethanamine, were synthesized with yield of 61.4, 66.7, 78, 75.2, 73%, respectively.
Synthesized compounds were evaluated for analgesic and antiinflammatory activities.
Compound 5(a), 5(c) and 5(d) showed maximum percentage inhibition of paw edema
i.e., 51.19, 52.8 and 50%, respectively, as compare to standard drug diclofenac
sodium, at dose of 200 mg kg-1. Compound 5(c) and 5(d) showed maximum
analgesic activity with lapse time of 6.94±0.15 and 6.99±0.22°C,
respectively. All the synthesized compounds were characterized on the basis
of their elemental analysis, IR and 1HNMR spectroscopic data. All
the tested compounds have shown moderate to good antiinflammatory activity by
carrageenan-induced rat paw edema method as well as analgesic activity on Eddy’s
hot plate.
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