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Current Research in Chemistry
  Year: 2012 | Volume: 4 | Issue: 4 | Page No.: 99-109
DOI: 10.3923/crc.2012.99.109
Synthesis of 2,4,5-Triphenylimidazoles Novel Mannich Bases as Potential Antiinflammatory and Analgesic Agents
Rashmi Arora, N.S. Gill, Ramit Kapoor, Amit Aggarwal and A.C. Rana

Abstract:
The 2,4,5-triphenylimidazole was synthesized by refluxing benzoin, benzaldehyde and ammonium acetate in equimolar quantities. The Mannich bases were synthesized by using abstractable hydrogen present in 2,4,5-triphenylimidazole because various drugs obtained from Mannich reaction have proved more effective and less toxic than their parent drugs. Various Mannich Bases of 2,4,5-triphenylimidazole i.e., 5(a); 5-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole,5(b);5-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole, 5(c); 3-(2,4,5-triphenyl-1H-imidazol-1-yl) methyl)morpholine, 5(d); N,N-dimethy l(2,4,5-triphenyl-1H-imidazol-1-yl)methanamine, 5(e); N-ethyl-N-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl) ethanamine, were synthesized with yield of 61.4, 66.7, 78, 75.2, 73%, respectively. Synthesized compounds were evaluated for analgesic and antiinflammatory activities. Compound 5(a), 5(c) and 5(d) showed maximum percentage inhibition of paw edema i.e., 51.19, 52.8 and 50%, respectively, as compare to standard drug diclofenac sodium, at dose of 200 mg kg-1. Compound 5(c) and 5(d) showed maximum analgesic activity with lapse time of 6.94±0.15 and 6.99±0.22°C, respectively. All the synthesized compounds were characterized on the basis of their elemental analysis, IR and 1HNMR spectroscopic data. All the tested compounds have shown moderate to good antiinflammatory activity by carrageenan-induced rat paw edema method as well as analgesic activity on Eddy’s hot plate.
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How to cite this article:

Rashmi Arora, N.S. Gill, Ramit Kapoor, Amit Aggarwal and A.C. Rana, 2012. Synthesis of 2,4,5-Triphenylimidazoles Novel Mannich Bases as Potential Antiinflammatory and Analgesic Agents. Current Research in Chemistry, 4: 99-109.

DOI: 10.3923/crc.2012.99.109

URL: https://scialert.net/abstract/?doi=crc.2012.99.109

 
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