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Current Research in Chemistry

Year: 2011 | Volume: 3 | Issue: 1 | Page No.: 49-61
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Authors

Sinem Gokturk

Umran Var

Keywords

Research Article

Effect of Ethanol on Partition and Binding Equilibrium of Phenothiazine in Anionic and Nonionic Micellar Solutions

Sinem Gokturk and Umran Var
This work deals with the solution behavior of a poorly soluble model drug, phenothiazine (PHT), under combined use of anionic Sodium Dodecyl Sulfate (SDS) and nonionic surfactants TritonX-100 (TX100) in the presence of various amount of ethanol. The characteristics of interaction and distribution of PHT were studied spectrophotometrically and quantified in terms of binding constants and micelle-water partition coefficients. Surface tension studies have been applied to identify the surface and bulk properties of the drug PHT in water-ethanol medium as a function of surfactant concentration ranging from premicellar to postmicellar region. When various amount of ethanol (v/v) were added to the aqueous surfactant solutions, it has been seen that its effect on the solubility depended on the combination of the surfactant and the ethanol concentration. Both binding and partition of PHT to SDS and TX100 micelles at low concentration diminished and totally inhibited at a certain concentration. Presence of ethanol has more pronounced inhibitory effect on incorporation of PHT to SDS than TX100 micelles. The results obtained from the different approaches and methods are in good agreement for the effect of ethanol on decreasing the interaction of PHT with micelles.
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