Effect of Ethanol on Partition and Binding Equilibrium of Phenothiazine in Anionic and Nonionic Micellar Solutions


	Current Research in Chemistry
	Year: 2011 \| Volume: 3 \| Issue: 1 \| Page No.: 49-61 DOI: 10.3923/crc.2011.49.61

Effect of Ethanol on Partition and Binding Equilibrium of Phenothiazine in Anionic and Nonionic Micellar Solutions

Sinem Gokturk and Umran Var

Abstract: This work deals with the solution behavior of a poorly soluble model drug, phenothiazine (PHT), under combined use of anionic Sodium Dodecyl Sulfate (SDS) and nonionic surfactants TritonX-100 (TX100) in the presence of various amount of ethanol. The characteristics of interaction and distribution of PHT were studied spectrophotometrically and quantified in terms of binding constants and micelle-water partition coefficients. Surface tension studies have been applied to identify the surface and bulk properties of the drug PHT in water-ethanol medium as a function of surfactant concentration ranging from premicellar to postmicellar region. When various amount of ethanol (v/v) were added to the aqueous surfactant solutions, it has been seen that its effect on the solubility depended on the combination of the surfactant and the ethanol concentration. Both binding and partition of PHT to SDS and TX100 micelles at low concentration diminished and totally inhibited at a certain concentration. Presence of ethanol has more pronounced inhibitory effect on incorporation of PHT to SDS than TX100 micelles. The results obtained from the different approaches and methods are in good agreement for the effect of ethanol on decreasing the interaction of PHT with micelles.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	An Exhaustive Review on Solubility Enhancement for Hydrophobic Compounds by Possible Applications of Novel Techniques

•	Thermodynamic and Polymeric Inhibitors Effects on Methane Gas Hydrate Formation

•	A Review on Novel Therapeutic Strategies for the Enhancement of Solubility for Hydrophobic Drugs through Lipid and Surfactant Based Self Micro Emulsifying Drug Delivery System: A Novel Approach

How to cite this article:

Sinem Gokturk and Umran Var, 2011. Effect of Ethanol on Partition and Binding Equilibrium of Phenothiazine in Anionic and Nonionic Micellar Solutions. Current Research in Chemistry, 3: 49-61.

DOI: 10.3923/crc.2011.49.61

URL: https://scialert.net/abstract/?doi=crc.2011.49.61

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar

Follow @scialert

Science Alert