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Current Research in Bacteriology
  Year: 2022 | Volume: 15 | Issue: 1 | Page No.: 1-7
DOI: 10.3923/crb.2022.1.7
 
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Antimicrobial Susceptibility Profile and Immune Response of Bacteria Isolated from Urinary Tract Infections

Sarah A. Yousef and M. Ohood

Abstract:
Background and Objective: Urinary tract infections (UTI) forms the largest single group of hospital-acquired infections and accounts for about 35 % of total nosocomial infections. This study aimed to detect the prevalence and antibiotic resistance profile of uropathogenic bacterial infection also to determine the immune response of infected patients. Materials and Methods: A hundred patients with clinical symptoms of UTI were investigated, 63% females and 37% males. About 5 mL of clean-catch midstream urine of patients was collected. Bacterial isolation and antimicrobial sensitivity profiles were applied on all collected urine samples. Serum samples were also collected for measuring phagocytosis and IgG levels. Results: Obtained data revealed, E. coli was the predominant uropathogenic organism (40 isolates), followed by K. pneumoniae (30 isolates), P. mirabilis (16 isolates), Staph. saprophytic (10 isolates) and Enterococcus faecalis (4 isolates). Obtained data, E. coli, were highly sensitive to Co-trimoxazole, Ceftriaxone and Imipenem (95%), while K. pneumonia was sensitive to Imipenem 66% and Nitrofurantoin 63%. Proteus mirabilis was sensitive to Amikacin 25% while S. saprophytic and Enterococcus faecalis were sensitive to Amikacin 20% and 25%, respectively. ESBL-producing organisms almost highly occur in female patients (65%) than male patients (27%). Phagocytic percentage and phagocytic index were elevated in patients infected with E. coli, also IgG titer was higher in E. coli infected patients (4.47) in comparison with other infected patients. Conclusions: E. coli is the most common isolated bacteria from urinary tract infections, a patient infected with E. coli showed high levels of CRP, phagocytosis and IgG. Much needed information to clinicians on the prevalence of antimicrobial susceptibility testing for judicial use of drugs and proper institution of therapy. This study underlined the importance of adequate antimicrobial prescription for UTIs to avoid multidrug resistance.
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How to cite this article:

Sarah A. Yousef and M. Ohood, 2022. Antimicrobial Susceptibility Profile and Immune Response of Bacteria Isolated from Urinary Tract Infections. Current Research in Bacteriology, 15: 1-7.

DOI: 10.3923/crb.2022.1.7

URL: https://scialert.net/abstract/?doi=crb.2022.1.7

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