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Current Research in Bacteriology
  Year: 2021 | Volume: 14 | Issue: 1 | Page No.: 1-9
DOI: 10.3923/crb.2021.1.9
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Antimicrobial Susceptibility Profile of Neonatal Infection and Immune Response Pattern

Sarah A. Yousef and W. Soliman

Background and Objective: Neonatal bacterial infections are considered the major causes of mortality and morbidity among neonates in developing countries. This study is aimed to study the bacterial pathogens causing neonatal infections, their antimicrobial susceptibility profile and the immune response of neonates against bacterial infection. Materials and Methods: About 150 samples were isolated from the neonatal intensive care unit. Bacteriological identification and susceptibility testing were done to collect samples by using the VITEK system. Collected serum samples were examined for determination of C-reactive Protein (CRP), Serum Amyloids A (SAA) and lysosomal activity. Results: The incidence of Gram-positive and Gram-negative organisms represented 36 and 64% respectively of culture isolates. Obtained results show many patterns of isolates and their antimicrobial susceptibility, Klebsiella showed a resistance rate to ampicillin of (88.9%). For Streptococcus all isolates were inhibited by levofloxacin. Results revealed a high level of C-reactive Protein (CRP), lysozyme and Serum Amyloids A (SAA) in the sepsis neonates group in comparison with other groups. Conclusions: Although bacterial infections in neonates are still manageable by the commonly used antibiotics, the development of some resistance to certain antibiotics is still a problem. Neonates bacterial infections caused elevation of some immunological parameters as SAA, CRP and Lysozyme.
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How to cite this article:

Sarah A. Yousef and W. Soliman, 2021. Antimicrobial Susceptibility Profile of Neonatal Infection and Immune Response Pattern. Current Research in Bacteriology, 14: 1-9.

DOI: 10.3923/crb.2021.1.9






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