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Asian Journal of Scientific Research
  Year: 2009 | Volume: 2 | Issue: 2 | Page No.: 113-118
DOI: 10.3923/ajsr.2009.113.118
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Blood Chemistry Changes as an Evidence of the Toxic Effects of Anionic Surfactant Sodium Dodecyl Sulfate

M.A.M. Wadaan and M. Mubarak

The objective of the present study was to investigate the toxic, damaging and irritative effects of repeated exposure to Sodium Dodecyl Sulfate (SDS) on rabbit skin. The animals were exposed to 5% solution of SDS for 8 weeks through skin brushing. All exposed rabbits manifested dermatitis and they were dull, depressed, emaciated and their body weight was decreased. Blood chemical parameters including alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), gama-glutamyl transferase (GGT), amylase, cholesterol, high density lipoproteins (HDLPs); triglycerides (TGs), creatinine, urea, glucose and potassium (K+) were estimated after 8 weeks of SDS exposure. All blood parameters except ALP and creatinine were significantly increased or decreased as compared to that of the controls. It is concluded that topical application of SDS is capable of damaging the skin with all signs of dermatitis. Further, SDS is capable of being adsorbed and penetrates through the skin barrier and thus reaches the internal organs such as liver to provoke systemic damages. The estimated blood parameters can potentially serve as biomarkers for assessing SDS toxicity. However, further studies are warranted to confirm this hypothesis.
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How to cite this article:

M.A.M. Wadaan and M. Mubarak, 2009. Blood Chemistry Changes as an Evidence of the Toxic Effects of Anionic Surfactant Sodium Dodecyl Sulfate. Asian Journal of Scientific Research, 2: 113-118.

DOI: 10.3923/ajsr.2009.113.118






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