
	Asian Journal of Poultry Science
	Year: 2018 \| Volume: 12 \| Issue: 1 \| Page No.: 1-6 DOI: 10.3923/ajpsaj.2018.1.6

Effects of Phyllanthus niruri and Curcuma longa on Liver and Renal Function of Escherichia coli Infected Layers

Sri Hartati, Tri Untari, Bambang Sutrisno and Ida Fitriana

Abstract: Background and Objective: Colibacillosis caused by Escherichia coli (E. coli ) and can cause economic losses in the poultry industry. One of the failures to overcome colibacillosis is the occurrence of bacterial resistance to some antibiotics. This study aimed to determine the effect of Phyllanthus niruri and Curcuma longa on the function of liver and renal layer chicken infected E. coli. Methodology: Fifty layers (DOC) were used in this study. After having infected E. coli, the layers were grouped into 5 and labeled with groups A, B, C, D and E. Group A was those who were treated with Curcuma longa 300 mg kg^–1, group B was treated with Phyllanthus niruri 500 mg kg^–1, group C was treated with equal dosage (1:1) of Curcuma longa and Phyllanthus niruri, group D was treated with Curcuma longa and Phyllanthus niruri whose dosages were 2: 1 and group E was without herbal treatment. Blood and organ samples were collected at 3 weeks post-herbal-treatment. Blood sample were used for examination of Alanine Transaminase (ALT) and creatinine concentration. Liver and renal samples were for histological examination. The results were analyzed by one-way ANOVA test. Results: Concentration of group B ALT was significantly different with group A, D and E (p<0.05). Group A had the highest ALT concentration i.e., 23.77±0.44 IU L^–1 and Group E (without herbal treatment) had the highest creatinine concentration i.e., 0.38±0.02 mg dL^–1. Creatinine concentration of group B was significantly different with all treatment groups (p<0.05). Histological observation of liver organs of group A showed infiltration of heterophile cells in the kiernan trigonum areas. Histological observation of renal organs showed that all groups were normal and there was no pathology. Conclusion: Phyllanthus niruri does not cause toxic effects for 21 days, so it can be alternative in the treatment of infectious disease of diarrhea caused by E. coli.

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How to cite this article:

Sri Hartati, Tri Untari, Bambang Sutrisno and Ida Fitriana, 2018. Effects of Phyllanthus niruri and Curcuma longa on Liver and Renal Function of Escherichia coli Infected Layers. Asian Journal of Poultry Science, 12: 1-6.

DOI: 10.3923/ajpsaj.2018.1.6

URL: https://scialert.net/abstract/?doi=ajpsaj.2018.1.6

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