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Asian Journal of Epidemiology
  Year: 2020 | Volume: 13 | Issue: 2 | Page No.: 47-53
DOI: 10.3923/aje.2020.47.53
 
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Reactivation of Human Papillomavirus in the Glans Penis Persists for a Long time in Japanese Male Cases

Tadaichi Kitamura , Motofumi Suzuki, Yasuhiro Koyama, Yuka Kawata, Miho Sumita and Kazuyoshi Shigehara

Abstract:
Background and Objective: HPV is known to cause uterine cervical cancer. HPV in the glans penis may be the causative agent for female cervical cancer. Probably, men infect women with HPV by sexual intercourse. However, it is said that mean HPV elimination time was 6 to 8 months. Supposedly, it is too short to infect women. In order to clarify long term persistence of HPV, 31 patients were examined repeatedly 2 to 5 times for detecting HPV infection in the glans during 1 to 9 years. Materials and Methods: Cells were collected with a saline-wet cotton swab which was used to rub the entire surface of the glans. DNA was extracted from the cells of the glans. HPV-DNA and genotyping were evaluated using the GENOSEARCH-HPV 31 kit in 31 cases (94 samples in total) adopting PCR method. Results: About 2/3 (67.7%) showed continuous shedding of almost the same HPV type(s), while HPV(s) was intermittently detected in about 1/3 (32.3%). These data indicate that reactivation of HPV is occurring every moment in about 2/3 of cases. However, 1/3 of the cases may reactivate intermittently. Additionally, HPV was demonstrated to persist at least 9 years in the glans. Conclusion: HPV in the glans is supposed to persist for a long time and to be almost always shed to the outside from more than 2/3 of the patients once it is infected with HPV regardless of their age. However, in the rest of the cases (1/3 of the patients), HPV is shed intermittently.
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How to cite this article:

Tadaichi Kitamura, Motofumi Suzuki, Yasuhiro Koyama, Yuka Kawata, Miho Sumita and Kazuyoshi Shigehara, 2020. Reactivation of Human Papillomavirus in the Glans Penis Persists for a Long time in Japanese Male Cases. Asian Journal of Epidemiology, 13: 47-53.

DOI: 10.3923/aje.2020.47.53

URL: https://scialert.net/abstract/?doi=aje.2020.47.53

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