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American Journal of Drug Discovery and Development
  Year: 2014 | Volume: 4 | Issue: 4 | Page No.: 241-247
DOI: 10.3923/ajdd.2014.241.247
 
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Therapeutic Potentials of Nigerian Insect-propolis Against the Malarial Parasite, Plasmodium berghei (Haemosporida: Plasmodidae)

Kayode I. Olayemi

Abstract:
This study reports the results of bio-assay of extract of Nigerian honey-bee propolis against Plasmodium berghei. Extract was tested for acute oral toxicity anti-plasmodial efficacy following standard protocols, using15 healthy mice experimentally infected with P. berghei. The mice were randomized into three groups and intra-peritoneally injected daily with 0.2 mL kg-1 body weight saline solution (Negative Control); 600 mg kg-1 (Test experiment) and 5 mg kg-1 Chloroquine diphosphate (Positive Control). Thin blood smear was used to determine levels of parasitaemia while, Erythrocyte Packed Cell Volume (PCV) was estimated Days 0, 4 and 7. The results showed that the extract significantly (p<0.05) reduced level of parasitaemia in the treated mice, with peak activity recorded on the last day of observation; a pattern distinctly different from the positive Control. There was a general increase in PCV till Day 4 before dropping significantly, especially. Survivorship of mice treated with extract was not significantly different from those treated Chloroquine.
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How to cite this article:

Kayode I. Olayemi , 2014. Therapeutic Potentials of Nigerian Insect-propolis Against the Malarial Parasite, Plasmodium berghei (Haemosporida: Plasmodidae). American Journal of Drug Discovery and Development, 4: 241-247.

DOI: 10.3923/ajdd.2014.241.247

URL: https://scialert.net/abstract/?doi=ajdd.2014.241.247

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