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American Journal of Drug Discovery and Development

Year: 2013 | Volume: 3 | Issue: 2 | Page No.: 32-46
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Authors

J.K. Akintunde

J.K. Akintunde

J.A. Ajiboye

E.O. Siemuri

S.B. Oyelowo

O.J. Sunday

E.O. Abam

A.E. Irondi

Keywords

Erectile Dysfunction (ED) occurs in folk men which poses great threat to couples awaiting children. The liver is one of the most vital organs involved in drug detoxification process. However, the concomitant toxic effects of Viagra on liver with other tissues are unknown. The present study was aimed to elucidate the effects of therapeutic doses of orally administered Viagra on the antioxidant defense status of liver, kidney, spleen and lung tissues in healthy rats. Wistar healthy albino Rats were orally administered with various therapeutic doses (20 mg kg-1 b.wt.) of Sildenafil citrate (viagra) for 4 weeks exhibited mild hepatocyte necrosis, periportal cellular infiltration by mononuclear cells and no visible lesions in kidney cells. This is accompanied with non-significant elevated plasma alanine amino transaminase (ALT) and aspartic amino transaminase (AST) levels, decreased hepatic MDA level and increased levels of MDA in kidney, spleen and lung. GSH was increased in liver, kidney, spleen and decreased in lung. CAT and SOD activity were elevated in liver, kidney and spleen. Lung showed high activity of SOD and low activity of CAT. Hence, administration of Viagra potentiates both enzymatic and non-enzymatic antioxidants in liver, kidney and spleen while it may promote inflammatory response in male rats. The present study provides evidence for stabilizing antioxidant defense systems in liver, kidney, spleen and may be a contributory factor for lung inflammatory responses.
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