Evaluation of Bacterial Cellulose Produced Form Acetobacter xylinum as Pharmaceutical Excipient


	American Journal of Drug Discovery and Development
	Year: 2012 \| Volume: 2 \| Issue: 2 \| Page No.: 72-86 DOI: 10.3923/ajdd.2012.72.86

Evaluation of Bacterial Cellulose Produced Form Acetobacter xylinum as Pharmaceutical Excipient

P.K. Kulkarni, S. Anil Dixit and U.B. Singh

Abstract: Microcrystalline cellulose (Avicel 101, AV 101) has been widely used as the excipients for tablet formulation. The objective of this research was to produce cellulose from Acetobacter xylinum (A. xylinum) which is used as alternative excipient for tablet formulation instead of AV 101. The bacterium was isolated from kombucha tea preparation. Bacterial pellicle formation was cultivated in stationary conditions using a Herstin-Schramm nutrient (HS) medium. The produced Bacterial Cellulose (BC) was compared with AV 101 by carrying out Moisture Sorption Capacity (MSC), Loss on Drying (LOD), Scanning Electron Microscopy (SEM), FT-IR Spectroscopy, X-Ray diffraction analysis, micromeritic properties and compactibility studies. Comparisons revealed that MSC for AV 101 was higher when compared to BC due to crystalline nature of BC. LOD of BC was 4.635% which is required for good compression. The particles of BC were small sized densely packed reticulated structure consisting of fine thread like fibrils whereas AV 101 was irregularly large sized elongated structures. The IR spectra showed that there were no significant difference in the spectra of BC and AV 101. BC had higher crystallinity than AV 101. Micromeritic properties and compactibility studies showed that BC have high bulk density, better flow property, easy fragmentation of the particles and rearrangement at a lower compression load, lesser elastic recovery and higher tensile strength than AV 101. The result provides evidence that BC produced by HS medium can be suitably used as pharmaceutical excipient for tablet formulation instead of AV 101.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Effect of Polyethylene Glycol and Sodium Lauryl Sulphate on the Compaction Characteristics of Eudragit and Drug Release from its Matrix

•	Evaluation of Gellan Gum as a Granulating Agent for Chloroquine Phosphate Tablets

•	Study of Nano-fiber Cellulose Production by Glucanacetobacter xylinum ATCC 10245

•	Production of Cellulose I Microfibrils from Rhizobium sp. and its Wound Healing Activity on Mice

How to cite this article:

P.K. Kulkarni, S. Anil Dixit and U.B. Singh, 2012. Evaluation of Bacterial Cellulose Produced Form Acetobacter xylinum as Pharmaceutical Excipient. American Journal of Drug Discovery and Development, 2: 72-86.

DOI: 10.3923/ajdd.2012.72.86

URL: https://scialert.net/abstract/?doi=ajdd.2012.72.86

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services

Follow @scialert

Science Alert