
	American Journal of Drug Discovery and Development
	Year: 2012 \| Volume: 2 \| Issue: 1 \| Page No.: 32-39 DOI: 10.3923/ajdd.2012.32.39

Targeting Virulence: Novel Effect of Myristica fragrans on Melanisation and Conidiation of Aspergillus niger

V. Pooja, Hina Sanwal, Seema Bhatnagar and Ashwani K. Srivastava

Abstract: Myristica fragrans HOUTT has been traditionally used by Asian Indians to treat stomach pains, dysentery, vomiting and the symptoms of malaria. It is also chewed to prevent foul breath. The present study was carried out to elucidate the antifungal effect of four extracts; hexane, chloroform, methanolic and ethanolic extract obtained from Mace. The extracts were concentrated and re-suspended in DMSO. MIC₈₀ was calculated by micro broth dilution method. Results have revealed the extracts to have good antifungal activity against Aspergillus niger and methanol and hexane extracts have been found to be most effective. Methanol and hexane extracts were also associated with de-melanization of Aspergillus niger. Further analysis revealed difference in the structure of the hyphal cell wall of methane and hexane extract treated cells.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Determination of Antibacterial Activity of Essential Oil of Myristica fragrans Houtt. using Tetrazolium Microplate Assay and its Cytotoxic Activity Against Vero Cell Line

•	Antibacterial Effect of Component of Terminalia muelleri Benth. against Staphylococcus aureus

•	Effects of Scrophularia striata Ethanolic Leaves Extracts on Staphylococcus aureus

•	Antibacterial and Antifungal Survey in Plants used in Indigenous Herbal-Medicine of South East Regions of Iran

•	Antimicrobial Activity of Certain Plants used in Turkish Traditional Medicine

How to cite this article:

V. Pooja, Hina Sanwal, Seema Bhatnagar and Ashwani K. Srivastava, 2012. Targeting Virulence: Novel Effect of Myristica fragrans on Melanisation and Conidiation of Aspergillus niger. American Journal of Drug Discovery and Development, 2: 32-39.

DOI: 10.3923/ajdd.2012.32.39

URL: https://scialert.net/abstract/?doi=ajdd.2012.32.39

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services

Science Alert