Abstract:
The aim of the present study was to enhance the dissolution rate of Itraconazole (ITZ) by a simple solid dispersion method (melt method). Binary and ternary ITZ systems were prepared using different polymers including crystallization inhibiting polymers (Pluronic F68, Pluronic F127, Eudragit EPO and polyvinyl pyyrolidone K25) at different ratios. The prepared solid dispersions of itraconazole were characterized by differential scanning calorimetry, X-Ray diffraction and infrared spectroscopy. All of the prepared systems showed faster and higher dissolution rates compared to raw and glassy ITZ. Stability studies of selected systems demonstrated that the itraconazole/Pluronic F127/Eduragit EPO (1:1:0.5), T6 ternary system was chemically (absence of degradation products) and physically stable (stable dissolution rate and negligible change in drug crystallinity) after three months of storage under different conditions.
Alia A. Badawi, Mohamed Ahmed El-Nabarawi, Doaa Ahmed El-Setouhy and Sami A. Alsammit, 2011. Characterization and Stability Testing of Itraconazole Solid Dispersions Containing Crystallization Inhibitors. American Journal of Drug Discovery and Development, 1: 144-159.
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