• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. American Journal of Drug Discovery and Development
  2. Vol 1 (2), 2011
  3. 105-120
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

American Journal of Drug Discovery and Development

Year: 2011 | Volume: 1 | Issue: 2 | Page No.: 105-120
DOI: 10.3923/ajdd.2011.105.120

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 361

Search


Authors


S.  Ramachandran

S. Ramachandran

LiveDNA: 91.3457

G. Thirumurugan


M.D. Dhanaraju


Keywords


  • in vivo gastric activity
  • controlled release
  • duodenal antiulcer activity
  • Glutaraldehyde Saturated Toluene (GST)
  • ranitidine
  • Chitosan
Research Article

Development and Evaluation of Biodegradable Chitosan Microspheres Loaded with Ranitidine and Cross Linked with Glutaraldehyde

S. Ramachandran S.  Ramachandran's LiveDNA, G. Thirumurugan and M.D. Dhanaraju
The present study aimed at the formulation of biodegradable chitosan microspheres loaded with ranitidine to overcome the poor bioavailability and frequent dose administration. Chitosan microsphere was prepared by simple emulsification technique by glutaraldehyde crosslinking. Various process variable and formulation variable such as speed of emulsification, cross linking time, drug/polymer ratio, volume of cross linking agent and volume of surfactant were optimized. Formulated microspheres were characterized for its entrapment efficiency, drug loading, in vitro drug release, Kinetics of drug release, surface morphology, particle size analysis, Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) thermal analysis. The characterized ranitidine microsphere formulations were investigated for in vivo gastric and duodenal antiulcer activity. The characterization of the fabricated microspheres showed smooth surface with narrow particle size distribution and entrapment efficiency upto 84%. The prepared microspheres exhibited a controlled drug release of 74% over a period of 24 h with initial burst release of 35% in the first 2 h. The FTIR and DSC reports showed that there was no potential drug interaction between the drug and polymer. In vivo studies shows that gastric volume, pH, total acidity and ulcer index of formulated ranitidine microspheres were significantly reduced as 2.67 mL, 5.59, 110 mEq L-1 and 1.74, respectively and also there is no evidence of extra tissue damage as seen in the biopsy report. From the data obtained it can be concluded that the chitosan microspheres could be considered as a potential biodegradable carrier for controlled drug delivery of ranitidine.
PDF Fulltext XML References Citation

How to cite this article

S. Ramachandran, G. Thirumurugan and M.D. Dhanaraju, 2011. Development and Evaluation of Biodegradable Chitosan Microspheres Loaded with Ranitidine and Cross Linked with Glutaraldehyde. American Journal of Drug Discovery and Development, 1: 105-120.

DOI: 10.3923/ajdd.2011.105.120

URL: https://scialert.net/abstract/?doi=ajdd.2011.105.120

Related Articles

A Review on Novel Therapeutic Strategies for the Enhancement of Solubility for Hydrophobic Drugs through Lipid and Surfactant Based Self Micro Emulsifying Drug Delivery System: A Novel Approach
Silk Fibroin/Chitosan Blend Films Loaded Methylene Blue as a Model for Polar Molecular Releasing: Comparison between Thai Silk Varieties

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved