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Asian Journal of Clinical Nutrition
  Year: 2017 | Volume: 9 | Issue: 3 | Page No.: 97-103
DOI: 10.3923/ajcn.2017.97.103
 
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The Effect of Kersen Juice on Lipid Profile of Spargue Dawley Rats: A Randomized Controlled Trial

Toto Sudargo , Indwiani Astuti, Eti Nuwening Sholikhah, Rasita Amelia, Laila Maknunah, M. Risnhukathulistiwi and Yosephin Anandati Pranoto

Abstract:
Background and Objective: Vitamin C is an antioxidant that has been linked to cholesterol metabolism and it’s ability to reduce level of cholesterol, triglycerides and low density lipoprotein (LDL) in patients with hyperlipidemia. Kersen is a fruit that is easily found in Indonesia but fail to utilize it fully. Kersen is rich in vitamin C and contains flavonoids, phenols, niacin and beta-carotene which act as antioxidant agents. The aim of this study was to analyze the beneficial effects of kersen juice on lipid profile of Spargue Dawley rats. Materials and Methods: This study use a randomized controlled trial (RCT) method. Twenty five adult male Sprague-Dawley rats were divided into five groups. The first two groups were controls: i). Group 1 = no high fat diet (HFD) without kersen juice, ii). Group 2 = HFD without kersen juice. The three treatment groups are: i). Group 3 = HFD+0.9 mL/200 g body weight (BW) of kersen juice, ii) Group 4 = HFD+1.8 mL/200 g BW of kersen juice and iii) Group 5 = HFD+3.6 mL/200 g BW. All groups were treated for 2 weeks. Blood was drawn to examine the lipid profile before and after treatment was given. Mann-Whitney test was performed to determine the significant differences p<0.05 between groups. Results: The increased level of high density lipoprotein (HDL) was significantly different (p<0.05) with the treatment given. No differences were found between groups of treatment on the level of cholesterol, triglycerides and LDL respectively p>0.116, p>0.383 and p>0.052. Conclusion: It was concluded that the administration of kersen juice can significantly increase HDL up to 2.68 mg dL–1 but not significantly change the total cholesterol, tryglicerids and LDL in rats with HFD in this study.
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How to cite this article:

Toto Sudargo, Indwiani Astuti, Eti Nuwening Sholikhah, Rasita Amelia, Laila Maknunah, M. Risnhukathulistiwi and Yosephin Anandati Pranoto, 2017. The Effect of Kersen Juice on Lipid Profile of Spargue Dawley Rats: A Randomized Controlled Trial. Asian Journal of Clinical Nutrition, 9: 97-103.

DOI: 10.3923/ajcn.2017.97.103

URL: https://scialert.net/abstract/?doi=ajcn.2017.97.103

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