This study includes new methods to study keloid and hypertrophic scars, which are morphometeric study and the use of tissue engineering technique; this may lead to find a new alternative way in Keloid management. Morphometeric analysis reflects the nature of the keloidal cells, which appear with different dimension compared with normal fibroblasts and hypertrophic cells. The tissue engineering results indicate that there is significant increase in the cell length when cultured on topography. Morphometic analysis indicate that keloidal cells shorter than normal fibroblasts, while keloidal cells adhere to grooved topography appeared longer than normal fibroblasts. This revealed that keloidal cells response to topography by aligned and increase in length.