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Asian Journal of Biological Sciences

Year: 2016 | Volume: 9 | Issue: 1-2 | Page No.: 41-46
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Authors

Abdulrahman A.I. AL-Yahya

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Research Article

Interaction Between Myrrh and Glibenclamide on Organ Damage in Diabetic Rats, a Morphological Study

Abdulrahman A.I. AL-Yahya
Myrrh (Commiphora molmol Engl.) is a medicinal herb widely used in different herbal preparations and is reported to possess several pharmacological effects including antidiabetic action. The present study determines the effect of myrrh, glibenclamide and the effect of co-administration of myrrh with glibenclamide on organ damage due to diabetes in rats. Myrrh was administered at two different doses of 500 and 1000 mg kg–1 orally, while glibenclamide was given at a dose of 0.6 mg kg–1 orally. Diabetes was induced using alloxan using method for induction of type 2 diabetes in rats. The blood glucose levels were determined to confirm the induction of diabetes and just before sacrificing the animals. All the treatments were given for a period of two weeks after diabetes induction. The animals were sacrificed and the weight of kidney, liver and pancreas were determined. The organs were subjected to histopathological examination. Myrrh at both doses prevented organ damage to varying degrees and augmented the effect of glibenclamide in preventing organ damage. It was concluded that myrrh prevents organ damage in diabetic rats and potentiates the effect of glibenclamide probably due to its antidiabetic and antioxidant effects.
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Abdulrahman A.I. AL-Yahya, 2016. Interaction Between Myrrh and Glibenclamide on Organ Damage in Diabetic Rats, a Morphological Study. Asian Journal of Biological Sciences, 9: 41-46.

URL: https://scialert.net/abstract/?doi=ajbs.2016.41.46

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