Antibodies Against Plasmodium berghei Fraction Inhibit Parasite Propagation in vitro


	Asian Journal of Biological Sciences
	Year: 2013 \| Volume: 6 \| Issue: 5 \| Page No.: 265-270 DOI: 10.3923/ajbs.2013.265.270

Antibodies Against Plasmodium berghei Fraction Inhibit Parasite Propagation in vitro

Monica Nainta and H.S. Banyal

Abstract: Humoral response exhibited by a fraction of Plasmodium berghei is evaluated in the present study. Immunization of mice with S fraction (supernatant of 20,000 rpm centrifugation) of Plasmodium berghei exhibited high humoral immune response. S fraction contained proteins of molecular weight ranging from 23.15-205.00 kDa. The humoral response was serodiagnostically analyzed employing ELISA, IFA and in vitro invasion inhibition assays. Antimalarial antibodies significantly inhibited invasion of Plasmodium berghei in short-term invasion assay. From the in vitro culture study it was found that S fraction exhibits a high humoral response and sera of five out of ten immunized mice inhibited more than 50% of invasion of erythrocytes by P. berghei.

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How to cite this article:

Monica Nainta and H.S. Banyal, 2013. Antibodies Against Plasmodium berghei Fraction Inhibit Parasite Propagation in vitro. Asian Journal of Biological Sciences, 6: 265-270.

DOI: 10.3923/ajbs.2013.265.270

URL: https://scialert.net/abstract/?doi=ajbs.2013.265.270

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