• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Asian Journal of Biological Sciences
  2. Vol 5 (1), 2012
  3. 9-19
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Asian Journal of Biological Sciences

Year: 2012 | Volume: 5 | Issue: 1 | Page No.: 9-19

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 368

Search


Authors


Yahya S. Al-Awthan


Mohamed A. Al-Douis


Gamal H. El-Sokkary

Country: Egypt

Esam M. Aqlan


Keywords


  • Dimethoate
  • guinea pigs
  • oxidative stress
  • vitamins
Research Article

Dimethoate-induced Oxidative Stress and Morphological Changes in the Liver of Guinea Pig and the Protective Effect of Vitamin C and E

Yahya S. Al-Awthan, Mohamed A. Al-Douis, Gamal H. El-Sokkary and Esam M. Aqlan
Dimethoate (DM), an organophosphate insecticide, has been used worldwide in agriculture and domestic for several years which has led to a variety of negative effects in non target species including humans. Therefore, the present study investigated the ameliorative properties of vitamin C (vitC) and E (vitE) on DM toxicity of guinea pigs. The animal groups were orally administered with either vehicle, vitC (200 mg kg-1 body weight) and vitE (200 mg kg-1 body weight), 1/50 LD50 of DM (7 mg kg-1 b.w.) and 1/50 LD50 of DM + vitC and vitE daily for 28 days. Administration of DM resulted in a significant increase in the levels of various serum marker enzymes (AST ALT and ALP). Similarly, significant increase in Lipid Peroxidation (LPO) level while induced significant decreases in the activities of liver Catalase (CAT) and Glutathione-S-Transferase (GST). In contrast, co-administration of vitC and vitE to DM-treated animals restored most of these biochemical parameters to nearly normal levels. Also, DM induced histopathological alterations such as cytoplasmic vacuolization and degeneration in nuclei, congestion, an enlargement of the blood vessels and lymphocytes infiltration in the liver. These changes were ameliorated by vitamins co-administration. The results showed that co-treatment of vitE and vitC protected guinea pigs from DM-induced biochemical and histopathological changes.
PDF Fulltext XML References Citation

How to cite this article

Yahya S. Al-Awthan, Mohamed A. Al-Douis, Gamal H. El-Sokkary and Esam M. Aqlan, 2012. Dimethoate-induced Oxidative Stress and Morphological Changes in the Liver of Guinea Pig and the Protective Effect of Vitamin C and E. Asian Journal of Biological Sciences, 5: 9-19.

URL: https://scialert.net/abstract/?doi=ajbs.2012.9.19

Related Articles

Protective Role of Achillea biebersteinii Pretreatment on Dimethoate Induced Oxidative Stress in Guinea Pigs Liver
Effects of Aqueous Extract of Withania somnifera on Some Liver Biochemical and Histopathological Parameters in Male Guinea Pigs

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved