Research Article

**Fractions Isolated by Differential Centrifugation of Plasmodium berghei Induce Humoral Immune Response**

Plasmodium berghei when subjected to differential centrifugation resulted in various subcellular fractions. Immune sera obtained from mice immunized with PIII fraction (pellet at 24,000 g) showed very high antibody titres detected by ELISA and IFA as compared to other fractions. Mice immunized with these fractions along with placebo controls were also challenged with 1x10⁵ P. berghei infected erythrocytes. Mice immunized with PIII fraction showed complete in vivo protection against parasite. Purification of antigens through immunoadsorption revealed antigens exhibiting protection in vivo against parasite challenge. Such antigens may act as useful tool in a fight against malaria.

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Chhaya Pirta and H.S. Banyal, 2012. Fractions Isolated by Differential Centrifugation of Plasmodium berghei Induce Humoral Immune Response. Asian Journal of Biological Sciences, 5: 39-45.

URL: https://scialert.net/abstract/?doi=ajbs.2012.39.45

Asian Journal of Biological Sciences

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Chhaya Pirta

H.S. Banyal

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Research Article

**Fractions Isolated by Differential Centrifugation of Plasmodium berghei Induce Humoral Immune Response**

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