Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Asian Journal of Biological Sciences
  Year: 2011 | Volume: 4 | Issue: 6 | Page No.: 506-513
DOI: 10.3923/ajbs.2011.506.513
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Comparative Study of the Status of a Biomarker of Lipid Peroxidation (Malondialdehyde) in Patients with Plasmodium falciparum and Plasmodium vivax Malaria Infection

O.B. Idonije, O. Festus, O. Okhiai and U. Akpamu

Abstract:
Malaria infection has been found to be associated with lipid peroxidation accompanying reduction in antioxidant capacity of the infected patients especially Plasmodium falciparum infection. In this study, a biomarker of lipid peroxidation, Malondialdehyde (MDA) was evaluated in adult (18-45 years) Nigerian patients with Plasmodium falciparum and Plasmodium vivax malaria infection. The research group is comprised of fifty patients with P. falciparum and fifty with P.vivax malaria confirmed patients attending the outpatient department of University of Benin Health Services Department, University of Benin, Benin City. Their lipid peroxidation products (MDA) values estimated spectrophotometrically were compared to that of the control group who are fifty apparently healthy tested malaria negative subjects. Result showed a significant increase (p<0.05) in Malondialdehyde level in malaria positive patients (n = 100; 7.67±0.42 μM L-1) compared to the control; malaria negative patients (n = 50; 4.43±0.32 μM L-1). This increase in Malondialdehyde level was higher in P.vivax malaria patients (n = 50; 7.94±0.27 μM L-1) than in P. falciparum malaria (n = 50; 7.41±0.38 μM L-1) and increases as the degree of parasitaemia increases. Malondialdehyde activity in malaria was higher in males than in females and among the young adults than in the old adults. The study specified malaria to induced oxidative stress which is higher in male and in the young and as the degree of parasitaemia increases and more severe with P.vivax malaria infection. Conclusively, supplementation of diet with antioxidants along anti-malaria drugs during treatment of malaria patients is recommended.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis
  •    Assay of Glucose 6-phosphate Dehydrogenase Enzyme and its Correlation with Disease Prevalence in Patients with Plasmodium falciparum Malaria
  •    Effect of Malarial Treatments on Biochemical Parameters and Plasma pH of Mice Infected with Plasmodium berghei
  •    The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial
  •    Cytokines and Micronutrients in Plasmodium vivax Infection
How to cite this article:

O.B. Idonije, O. Festus, O. Okhiai and U. Akpamu, 2011. Comparative Study of the Status of a Biomarker of Lipid Peroxidation (Malondialdehyde) in Patients with Plasmodium falciparum and Plasmodium vivax Malaria Infection. Asian Journal of Biological Sciences, 4: 506-513.

DOI: 10.3923/ajbs.2011.506.513

URL: https://scialert.net/abstract/?doi=ajbs.2011.506.513

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

Curve Bottom