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Asian Journal of Biological Sciences
  Year: 2011 | Volume: 4 | Issue: 1 | Page No.: 44-52
DOI: 10.3923/ajbs.2011.44.52
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The Effects of Aqueous Ocimum gratissimum Leaf Extract on Some Biochemical and Hematological Parameters in Male Mice

A.W. Obianime, J.S. Aprioku and C. Esomonu

The present study is intended to investigate the dose-and time-dependent effects of the aqueous crude extract of O. grtissimum Linn. leaf (OG) on some biochemical and hematological parameters in the male mice. Animals were grouped into 3 (each containing 4 groups, n = 5) and orally administered with OG (11-88 mg kg-1) and observed for 1, 2 and 4 weeks, respectively. A fourth group was used as the control and given only distilled water for 4 weeks. While the serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, creatinine and total cholesterol were not significantly (p≤0.05) different in experimental animals compared to control animals, 1 week administration of OG significantly decreased the serum levels of urea and total protein in a dose-dependent manner. Furthermore, uric acid, total acid and prostatic acid phosphatases were increased during the fourth week of administration in OG-treated animals, compared to control animals. In addition, the first and second weeks of OG administrations resulted in dose-dependent reductions in PCV, Hb and neutrophils, with increase in WBC and lymphocyte counts. However, administration of OG for 4 weeks had no significant effects on the hematological parameters. The study shows that OG will cause anemia and may affect prostatic/testicular function in the mouse, depending on the duration of exposure to the animal.
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How to cite this article:

A.W. Obianime, J.S. Aprioku and C. Esomonu, 2011. The Effects of Aqueous Ocimum gratissimum Leaf Extract on Some Biochemical and Hematological Parameters in Male Mice. Asian Journal of Biological Sciences, 4: 44-52.

DOI: 10.3923/ajbs.2011.44.52






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